Recent trends in cancer survival across Europe between 2000 and 2004: A model-based period analysis from 12 cancer registries
Recent trends in cancer survival across Europe between 2000 and 2004: A model-based period analysis from 12 cancer registries
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DOI：
10.1016/j.ejca.2008.03.010
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发表时间：
2008-07-01
影响因子：
8.4
通讯作者：
Brenner, H.
中科院分区：
文献类型：
--
作者：
Gondos, A.;Bray, F.;Brenner, H.
背景：基于人群的癌症生存监测是癌症控制评估中的重要组成部分，但在使用传统分析技术报告最新的生存估计时存在固有的延迟。方法：我们基于来自欧洲不同地区的12个癌症登记的随访数据，使用基于模型的时间分析技术，研究了20种常见癌症在2000至2004年间的生存趋势。结果：2000至2004年间，前列腺癌、乳腺癌和结直肠癌患者的5年相对存活率显著上升，在12个参与的癌症登记中，分别有10、8和7个存活率有统计学意义。对于能够进行有效早期发现和治疗的癌症部位，患者预后的主要地理差异仍然存在，东欧国家普遍观察到生存率较低。结论：基于模型的时期分析能够及时监测基于人群的癌症生存率的最新趋势。对于结直肠癌和乳腺癌，确定的存活率上升可能(至少部分)是由于临床护理和疾病管理的改善。然而，持续的地理差异确实表明，整个欧洲的癌症负担有可能进一步减轻，不同护理领域的改善，包括二级预防、获得治疗进展以及肿瘤学护理的次级专科和区域化，都可能有助于实现这一目标。(C)2008爱思唯尔有限公司。保留所有权利。
Background: Monitoring population-based cancer survival is an essential component in the evaluation of cancer control, but subject to an inherent delay in the reporting of the most recent survival estimates with traditional techniques of analysis.Methods: We examined survival trends between the years 2000 and 2004 for 20 common cancers based on follow-up data from 12 cancer registries from diverse areas of Europe using model-based period analysis techniques. Results: Between 2000 and 2004, marked rises were seen in 5-year relative survival amongst patients with prostate, breast and colorectal cancer, which were statistically significant in 10, 8 and 7 of the 12 participating cancer registries, respectively. For cancer sites amenable to effective early detection and treatment, major geographical differences in patient prognosis still persisted, with a lower survival generally observed in Eastern European countries.Conclusion: Model-based period analysis enables the timely monitoring of recent trends in population -based cancer survival. For colorectal and breast cancers, the identified rises in survival are probably (at least partly) explained by the improvements in clinical care and the management of the disease. Nevertheless, persisting geographic differences do point to the potential for a further reduction in the burden of cancer throughout Europe, towards which improvements in diverse areas of care, including secondary prevention, access to advances in treatment as well as subspecialisation and regionalisation of oncologic care may all contribute. (C) 2008 Elsevier Ltd. All rights reserved.