Photothermal Efficiencies of Nanoshells and Nanorods for Clinical Therapeutic Applications
Photothermal Efficiencies of Nanoshells and Nanorods for Clinical Therapeutic Applications
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DOI：
10.1021/jp9003592
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发表时间：
2009-07-16
影响因子：
3.7
通讯作者：
Halas, Naomi J.
中科院分区：
文献类型：
--
作者：
Cole, Joseph R.;Mirin, Nikolay A.;Halas, Naomi J.
随着使用激光激发可调谐等离子体纳米粒子进行光热肿瘤消融的临床试验已经开始，增加对基于等离子体纳米粒子的光热加热功效的了解变得越来越紧迫。在这里，我们报告了 SiO2/Au 纳米壳、Au2S/Au 纳米壳和 Au 纳米棒的光热传导效率的比较研究，与依赖等离子体纳米颗粒光热响应的应用直接相关。我们将每种纳米粒子类型的实验光热传导效率与理论吸收效率进行比较。我们的分析假设纳米棒是随机定向的分布，就像肿瘤脉管系统中自然发生的那样。在我们的研究中，所研究的不同类型的纳米颗粒之间的光热传导效率相差 3 倍或更小。实验和理论都表明，颗粒尺寸在决定转导效率方面起着主导作用，较大的颗粒对于吸收和散射更有效，从而能够同时进行光热加热和生物成像对比度增强。
With clinical trials for photothermal tumor ablation using laser-excited tunable plasmonic nanoparticles already underway, increasing understanding of the efficacy of plasmonic nanoparticle-based photothermal heating takes on increased urgency. Here we report a comparative study of the photothermal transduction efficiency of SiO2/Au nanoshells, Au2S/Au nanoshells, and Au nanorods, directly relevant to applications that rely on the photothermal response of plasmonic nanoparticles. We compare the experimental photothermal transduction efficiencies with the theoretical absorption efficiencies for each nanoparticle type. Our analysis assumes a distribution of randomly oriented nanorods, as would occur naturally in the tumor vasculature. In our study, photothermal transduction efficiencies differed by a factor of 3 or less between the different types of nanoparticle studied. Both experiment and theory show that particle size plays a dominant role in determining transduction efficiency, with larger particles more efficient for both absorption and scattering, enabling simultaneous photothermal heating and bioimaging contrast enhancement.