High consumption of coffee is associated with decreased multiple sclerosis risk; results from two independent studies.
High consumption of coffee is associated with decreased multiple sclerosis risk; results from two independent studies.
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DOI：
10.1136/jnnp-2015-312176
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发表时间：
2016-05
期刊：
影响因子：
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通讯作者：
Alfredsson L
中科院分区：
文献类型：
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作者：
Hedström AK;Mowry EM;Gianfrancesco MA;Shao X;Schaefer CA;Shen L;Olsson T;Barcellos LF;Alfredsson L
以前关于咖啡因摄入量和多发性硬化症（MS）风险的研究得出了不确定的结果。我们的目的是调查咖啡的消费是否与MS的风险有关。使用两个人群代表性病例对照研究（瑞典的一项研究包括1620例病例和2788例对照，美国的一项研究包括1159例病例和1172例对照），根据回顾性数据收集，比较了具有不同咖啡消费习惯的参与者患MS的风险，通过计算OR和95%CI。Logistic回归模型针对广泛的潜在混杂因素进行了调整。与报告不喝咖啡的人相比，报告每天喝咖啡超过900 mL的人患MS的风险显著降低（瑞典研究中OR 0.70（95% CI 0.49至0.99），美国研究中OR 0.69（95% CI 0.50至0.96））。 随着咖啡消费量的增加，MS的几率降低，无论是在疾病发作时还是在疾病发作前5年或10年饮用咖啡。 根据在MS动物模型中的研究，高消费咖啡可能会降低发展MS的风险。咖啡因，咖啡的一种成分，具有神经保护特性，并已被证明可以抑制促炎细胞因子的产生，这可能是所观察到的关联的机制。然而，需要进一步的研究来确定是否暴露于咖啡因是所观察到的关联的基础，如果是这样，则需要评估其作用机制。
Previous studies on consumption of caffeine and risk of multiple sclerosis (MS) have yielded inconclusive results. We aimed to investigate whether consumption of coffee is associated with risk of MS. Using two population-representative case–control studies (a Swedish study comprising 1620 cases and 2788 controls, and a US study comprising 1159 cases and 1172 controls), participants with different habits of coffee consumption based on retrospective data collection were compared regarding risk of MS, by calculating ORs with 95% CIs. Logistic regression models were adjusted for a broad range of potential confounding factors. Compared with those who reported no coffee consumption, the risk of MS was substantially reduced among those who reported a high consumption of coffee exceeding 900 mL daily (OR 0.70 (95% CI 0.49 to 0.99) in the Swedish study, and OR 0.69 (95% CI 0.50 to 0.96) in the US study). Lower odds of MS with increasing consumption of coffee were observed, regardless of whether coffee consumption at disease onset or 5 or 10 years prior to disease onset was considered. In accordance with studies in animal models of MS, high consumption of coffee may decrease the risk of developing MS. Caffeine, one component of coffee, has neuroprotective properties, and has been shown to suppress the production of proinflammatory cytokines, which may be mechanisms underlying the observed association. However, further investigations are needed to determine whether exposure to caffeine underlies the observed association and, if so, to evaluate its mechanisms of action.