Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus
Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus
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DOI：
10.1523/jneurosci.15-07-05088.1995
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发表时间：
1995-07
期刊：
影响因子：
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通讯作者：
Z.-L. Chen;S. Yoshida;K. Kato;Y. Momota;J. Suzuki;T. Tanaka;J. Ito;H. Nishino;S. Aimoto;H. Kiyama;Sadao Shiosaka
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文献类型：
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作者：
Z.-L. Chen;S. Yoshida;K. Kato;Y. Momota;J. Suzuki;T. Tanaka;J. Ito;H. Nishino;S. Aimoto;H. Kiyama;Sadao Shiosaka
克隆了一个新的小鼠cDNA，其编码命名为neuropsin的蛋白质。北方和原位杂交分析表明，neuropsin mRNA的表达，特别是在边缘系统的小鼠大脑和定位在最高浓度的海马CA 1 -3亚区的锥体神经元。直接刺激海马和刺激杏仁核点燃引起海马锥体神经元neuropsin mRNA水平的显著变化。这种活性依赖性变化和特异性定位表明neuropsin参与海马可塑性。
A novel murine cDNA which encodes a protein designated neuropsin was cloned. Northern and in situ hybridization analyses demonstrated that neuropsin mRNA is expressed specifically in the limbic system of mouse brain and is localized at highest concentration in pyramidal neurons of the hippocampal CA1–3 subfields. Direct hippocampal stimulation and kindling induced by amygdaloid stimulation caused a significant bilateral change in neuropsin mRNA level in the hippocampal pyramidal neurons. The activity-dependent changes and the specific localization indicate that neuropsin is involved in hippocampal plasticity.