Degenerative age changes in white matter connectivity visualized in vivo using magnetic resonance imaging
Degenerative age changes in white matter connectivity visualized in vivo using magnetic resonance imaging
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DOI：
10.1093/cercor/12.7.767
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发表时间：
2002-07-01
期刊：
影响因子：
3.7
通讯作者：
Resnick, SM
中科院分区：
文献类型：
--
作者：
Davatzikos, C;Resnick, SM
通过磁共振成像（MRI）研究年龄对脑白质（WM）信号特征的影响。利用一种新的图像分析方法证明了WM退化的全局和局部模式。在WM中发现了显著的横截面和纵向年龄效应，主要是在左半球。重要的是，可能反映WM脱髓鞘的信号变化以及组织中水、蛋白质和矿物质含量的变化与体积变化无关。因此，组织特征的测量为广泛使用的脑萎缩测量提供了独特和互补的信息。此外，信号测量显示与年龄有更强的相关性，并且可能比体积测量作为临床前疾病的指标更敏感，因为它们反映了潜在组织组成的变化。据我们所知，我们的研究首次记录了WM纤维磁共振信号特征的纵向年龄和区域依赖变化，反映了衰老的潜在退行性影响。
Age effects on the signal characteristics of white matter (WM) were examined via magnetic resonance imaging (MRI). Global and local patterns of WM degeneration were demonstrated using a new image analysis methodology. Significant cross-sectional and longitudinal age effects were found in the WM, primarily in the left hemisphere. Importantly, signal changes, which likely reflect WM demyelination, and changes in water, protein and mineral content of tissue, were unrelated to volumetric changes. Thus, measures of tissue characteristics provide unique and complementary information to widely used measures of brain atrophy. Moreover, signal measurements displayed stronger associations with age and can potentially be more sensitive than volumetric measures as indicators of preclinical disease, because they reflect changes in the underlying tissue composition. To our knowledge, our study is the first documentation of longitudinal age- and region-dependent changes in magnetic resonance signal characteristics of WM fibers, reflecting underlying degenerative effects of aging.