Fetal Transcatheter Trileaflet Heart Valve Hemodynamics: Implications of Scaling on Valve Mechanics and Turbulence.
Fetal Transcatheter Trileaflet Heart Valve Hemodynamics: Implications of Scaling on Valve Mechanics and Turbulence.
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胎儿经导管三叶心脏瓣膜血流动力学：缩放对瓣膜力学和湍流的影响。
DOI：
10.1007/s10439-020-02475-3
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发表时间：
2020
影响因子：
3.8
通讯作者：
Dasi,LakshmiPrasad
中科院分区：
文献类型：
--
作者：
Hatoum,Hoda;Gooden,Shelley;Heitkemper,Megan;Blum,KevinM;Zakko,Jason;Bocks,Martin;Yi,Tai;Wu,Yen-Lin;Wang,Yadong;Breuer,ChristopherK;Dasi,LakshmiPrasad
关于肺胎儿瓣膜置换术或植入术的最佳方法的可用数据稀缺，因此有必要研究成人经导管瓣膜的实践是否可以转化为胎儿应用。本研究旨在评价胎儿尺寸三叶经导管肺动脉瓣膜与成人球囊扩张瓣膜相比的血流动力学特征和湍流特性，以评估使用动态相似性设计胎儿应用瓣膜的可能性。在脉冲复制器中评估了6 mm胎儿三叶瓣膜和26 mm SAPIEN 3瓣膜。进行粒子图像测速。评价了压力梯度（ΔP）、有效瓣口面积（EOA）、湍流分数（RF）、旋转指数（PI）和湍流应力。胎儿瓣和SAPIEN的Δ P分别为8.56 ± 0.139和7.76 ± 0.083 mmHg（p< 0.0001）;胎儿瓣膜和SAPIEN的EOA分别为0.10 ± 0.0007和2.1 ± 0.025 cm 2（p< 0.0001）;胎儿瓣膜的RF为2.35 ± 1.99%，SAPIEN为10.92 ± 0.11% PI值胎儿瓣膜组为0.404 ± 0.01，SAPIEN组为0.37 ± 0.07;胎儿瓣膜的流态为湍流，雷诺数达到约7000，而SAPIEN的流态在峰值速度时达到约20，000。胎儿瓣膜的湍流应力显著高于SAPIEN。在峰值收缩期，胎儿瓣膜的瞬时粘性剪切应力比SAPIEN高5.8倍，雷诺剪切应力高2.5倍。胎儿瓣膜植入导致湍流（特定于这种特定类型和设计的瓣膜）状态，这与与成人瓣膜相比具有不同流动特性的小瓣膜的预期情况不同。
The scarcity of data available on the best approach for pulmonary fetal valve replacement or implantation necessitate an investigation on whether practices using adult transcatheter valves could be translated to fetal applications. The objective of this study is to evaluate the hemodynamic characteristics and the turbulent properties of a fetal sized trileaflet transcatheter pulmonary valve in comparison with an adult balloon-expandable valve in order to assess the possibility of designing valves for fetal applications using dynamic similarity. A 6 mm fetal trileaflet valve and a 26 mm SAPIEN 3 valve were assessed in a pulse duplicator. Particle image velocimetry was performed. Pressure gradient (ΔP), effective orifice area (EOA), regurgitant fractions (RF), pinwheeling indices (PI) and turbulent stresses were evaluated. ΔPwas 8.56 ± 0.139 and 7.76 ± 0.083 mmHg with fetal valve and SAPIEN respectively (p< 0.0001); EOA was 0.10 ± 0.0007 and 2.1 ± 0.025 cm2with fetal valve and SAPIEN respectively (p< 0.0001); RF with the fetal valve was 2.35 ± 1.99% and with SAPIEN 10.92 ± 0.11% (p< 0.0001); PI with fetal valve was 0.404 ± 0.01 and with SAPIEN 0.37 ± 0.07; The flow regime with the fetal valve was turbulent and Reynolds numbers reached about 7000 while those with the SAPIEN reached about 20,000 at peak velocity. Turbulent stresses were significantly higher with fetal valve compared with SAPIEN. Instantaneous viscous shear stresses with fetal valve were 5.8 times higher than those obtained with SAPIEN and Reynolds shear stresses were 2.5 times higher during peak systole. The fetal valve implantation leads to a turbulent flow (specific to this particular type and design of valve) regime unlike what is expected of a small valve with different flow properties compared to adult valves.
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影响因子：
4.8
作者：
B. Jirgensons
通讯作者：
B. Jirgensons
来自抹香鲸肌红蛋白的 T 细胞抗原肽折叠为两亲性螺旋：免疫优势的可能决定因素？
DOI：
--
发表时间：
1989
期刊：
Peptide research
影响因子：
--
作者：
Lark,LR;Berzofsky,JA;Gierasch,LM
通讯作者：
Gierasch,LM
影响因子：
4.8
作者：
B. Jirgensons
通讯作者：
B. Jirgensons
影响因子：
2.9
作者：
MANAVALAN, P;JOHNSON, WC
通讯作者：
JOHNSON, WC
通过螺旋疏水矩分析确定含四吡咯蛋白质中螺旋区域的位置。
DOI：
--
发表时间：
1990
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Parker,W;Song,PS
通讯作者：
Song,PS