Therapeutic benefits of H(2)S in Alzheimer's disease.
Therapeutic benefits of H(2)S in Alzheimer's disease.
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H2S 对阿尔茨海默病的治疗效果
DOI：
10.1016/j.jocn.2014.01.006
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发表时间：
2014
影响因子：
2
通讯作者：
Tang Xiao-Qing
中科院分区：
文献类型：
--
作者：
Wei Hai-Jun;Li Xiang;Tang Xiao-Qing
硫化氢（H2S）是一种内源性气体介质，被发现调节哺乳动物系统的一系列生理和病理过程。近几十年来，科学界对H2S的生理和病理意义，特别是其在中枢神经系统（CNS）中的作用越来越感兴趣。H2S可以在中枢神经系统中作为神经调节剂，促进长时程增强，调节脑细胞内钙浓度和pH水平。H2S可以保护神经系统免受氧化应激、细胞凋亡或退化。这篇综述的目的是介绍目前对H2S作为治疗阿尔茨海默病（AD）的潜在药物的理解。H2S稳态失调与AD的病理过程有关。体内和体外研究的大量证据表明，H2S可以预防AD实验模型中的神经元损伤并减轻认知功能障碍。H2S在AD中保护作用的机制包括其抗氧化、抗凋亡和抗炎作用。我们认为H2S对阿尔茨海默病具有潜在的治疗价值。
Hydrogen sulfide (H2S), an endogenously generated gaseous mediator, has been discovered to regulate a series of physiological and pathological processes in mammalian systems. In recent decades scientific interest has grown in the physiological and pathological implications of H2S, specifically its role in the central nervous system (CNS). H2S can work in the CNS as a neuromodulator to promote long-term potentiation and regulate intracellular calcium concentration and pH level in brain cells. H2S may protect the nervous system from oxidative stress, apoptosis, or degeneration. The aim of this review is to present the current understanding of H2S as a potential agent for the treatment of Alzheimer’s disease (AD). Dysregulation of H2S homeostasis is implicated in the pathological processes of AD. Substantial evidence from bothin vivoandin vitrostudies shows that H2S prevents neuronal impairment and attenuates cognitive dysfunction in the experimental model of AD. The mechanisms underlying the protective role of H2S in AD involve its antioxidant, anti-apoptotic, and anti-inflammatory effects. We conclude that H2S has potential therapeutic value for the treatment of AD.