ENHANCED EXPRESSION OF THE DEVELOPMENTALLY REGULATED EXTRACELLULAR-MATRIX MOLECULE TENASCIN FOLLOWING ADULT BRAIN INJURY
ENHANCED EXPRESSION OF THE DEVELOPMENTALLY REGULATED EXTRACELLULAR-MATRIX MOLECULE TENASCIN FOLLOWING ADULT BRAIN INJURY
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DOI：
10.1073/pnas.89.7.2634
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发表时间：
1992-04-01
影响因子：
11.1
通讯作者：
STEINDLER, DA
中科院分区：
文献类型：
--
作者：
LAYWELL, ED;DORRIES, U;STEINDLER, DA
腱生素是一种细胞外基质分子，在神经系统的胚胎和出生后早期发育期间由年轻的星形胶质细胞合成和释放，并且其集中在新兴功能神经元单元周围的边界。 在成人神经系统中，只能检测到非常低水平的腱生蛋白。 发育过程中腱生蛋白的独特空间和时间分布表明其在早期功能模式中对神经元及其过程的引导和/或分离中发挥作用。 我们在这里显示，使用原位杂交和免疫细胞化学，成年小鼠小脑和大脑皮质的刺伤导致增强表达的腱生蛋白在周围的病变部位，这是与一个子集的胶质细胞酸性蛋白阳性星形胶质细胞的离散区域。 在损伤的成人大脑中，腱生蛋白上调可能直接参与再生失败，或通过其与抑制或促进神经突生长的其他糖缀合物的相互作用间接参与。
Tenascin is an extracellular matrix molecule synthesized and released by young astrocytes during embryonic and early postnatal development of the nervous system, and it is concentrated in boundaries around emerging functional neuronal units. In the adult nervous system, tenascin can be detected only in very low levels. Distinct spatial and temporal distributions of tenascin during developmental events suggest a role in the guidance and/or segregation of neurons and their processes within incipient functional patterns. We show here, using in situ hybridization and immunocytochemistry, that stab wounds of the adult mouse cerebellar and cerebral cortices result in an enhanced expression of tenascin in a discrete region around the lesion site that is associated with a subset of glial fibrillary acidic protein-positive astrocytes. Tenascin up-regulation in the lesioned adult brain may be directly involved in failed regeneration or indirectly involved through its interactions with other glycoconjugates that either inhibit or facilitate neurite growth.