Streptococcus pneumoniae Transposon Tn1545/Tn6003 Changes to Tn6002 Due to Spontaneous Excision in Circular Form of the erm(B)-and aphA3-Containing Macrolide-Aminoglycoside-Streptothricin (MAS) Element
Streptococcus pneumoniae Transposon Tn1545/Tn6003 Changes to Tn6002 Due to Spontaneous Excision in Circular Form of the erm(B)-and aphA3-Containing Macrolide-Aminoglycoside-Streptothricin (MAS) Element
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DOI：
10.1128/aac.01487-12
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发表时间：
2012-11-01
影响因子：
4.9
通讯作者：
Varaldoa, Pietro E.
中科院分区：
文献类型：
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作者：
Palmieri, Claudio;Mingoia, Marina;Varaldoa, Pietro E.
大环内酯-氨基糖苷-链丝菌素 (MAS) 元件类似于包含 erm(B) 和 aphA3 抗性决定子的 4.2-kb 插入，将肺炎链球菌转座子 Tn1545/Tn6003 与 Tn6002 区分开来。在这里，它被证明是一种不稳定的遗传元件，尽管它缺乏重组酶基因，但可以利用含有 erm(B) 的长直接重复序列作为 att 位点进行自发切除，从而可能导致损失。切除后（与 RecA 无关），Tn1545/Tn6003 变为 Tn6002。在携带 Tn1545/Tn6003 的肺炎球菌群体中，后者似乎与 Tn6002 共存。
The macrolide-aminoglycoside-streptothricin (MAS) element, an similar to 4.2-kb insertion containing erm(B) and aphA3 resistance determinants, distinguishes Streptococcus pneumoniae transposon Tn1545/Tn6003 from Tn6002. Here, it is shown to be an unstable genetic element that, although it lacks recombinase genes, can exploit long, erm(B)-containing direct repeats acting as att sites for spontaneous excision that may result in loss. Consequent to excision, which is RecA independent, Tn1545/Tn6003 changes to Tn6002. In pneumococcal populations harboring Tn1545/Tn6003, the latter appears to coexist with Tn6002.