Sarcoma Metabolomics: Current Horizons and Future Perspectives.
Sarcoma Metabolomics: Current Horizons and Future Perspectives.
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作者：
Esperança-Martins M;Fernandes I;Soares do Brito J;Macedo D;Vasques H;Serafim T;Costa L;Dias S
癌细胞能够承担的大量代谢适应不仅支持其生物合成活性，而且还满足其生物能量需求并保持其细胞内还原-氧化（氧化还原）平衡。焦点最近被放置在癌细胞增殖所采用的能量代谢重编程策略上。关于软组织和骨肉瘤代谢组学的知识相对较少。肉瘤代谢景观的进一步表征可能为诊断改进和新的治疗靶点识别铺平道路，对肉瘤患者有益。这篇综述涵盖了癌症代谢组学的最新知识，并详细探讨了软组织和骨肉瘤代谢组学的最新证据。
The vast array of metabolic adaptations that cancer cells are capable of assuming, not only support their biosynthetic activity, but also fulfill their bioenergetic demands and keep their intracellular reduction–oxidation (redox) balance. Spotlight has recently been placed on the energy metabolism reprogramming strategies employed by cancer cells to proliferate. Knowledge regarding soft tissue and bone sarcomas metabolome is relatively sparse. Further characterization of sarcoma metabolic landscape may pave the way for diagnostic refinement and new therapeutic target identification, with benefit to sarcoma patients. This review covers the state-of-the-art knowledge on cancer metabolomics and explores in detail the most recent evidence on soft tissue and bone sarcoma metabolomics.
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影响因子：
5.2
作者：
Conciatori F;Ciuffreda L;Bazzichetto C;Falcone I;Pilotto S;Bria E;Cognetti F;Milella M
通讯作者：
Milella M
影响因子：
20.8
作者：
Elia I;Haigis MC
通讯作者：
Haigis MC
影响因子：
11.2
作者：
Di Gialleonardo V;Aldeborgh HN;Miloushev V;Folkers KM;Granlund K;Tap WD;Lewis JS;Weber WA;Keshari KR
通讯作者：
Keshari KR
影响因子：
--
作者：
Cubitt, Christopher L.;Menth, Jiliana;Reed, Damon R.
通讯作者：
Reed, Damon R.
影响因子：
3.4
作者：
Crago AM;Singer S
通讯作者：
Singer S