Sleep Health at the Genomic Level: Six Distinct Factors and Their Relationships With Psychopathology.
Sleep Health at the Genomic Level: Six Distinct Factors and Their Relationships With Psychopathology.
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DOI：
10.1016/j.bpsgos.2022.07.002
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发表时间：
2023-07
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影响因子：
--
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中科院分区：
文献类型：
--
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睡眠不佳与许多负面的健康后果有关，包括精神病理学的多个方面。在过去的十年里，睡眠研究人员一直主张将睡眠健康的概念作为一种可改变的健康行为来减轻或预防这些结果。睡眠健康维度通常包括睡眠效率、持续时间、满意度、规律性、时间安排和白天的警觉性。然而，对于如何在表型和基因水平上最好地操作睡眠健康，还没有达成共识。在一些研究中，具体的睡眠健康领域是单独检查的，而在另一些研究中，睡眠健康领域是一起检查的(例如，使用总的睡眠健康评分)。在这里，我们使用基因组结构方程模型对不同的睡眠健康因素模型进行了比较，这些模型基于先前发表的自我报告和活动睡眠测量的全基因组关联研究的汇总统计数据，有效样本量高达452,633。我们最适合的睡眠健康模型有6个与6个睡眠健康领域相关的遗传因素：昼夜节律偏好、效率、警觉性、持续时间、非失眠和规律性。除昼夜节律偏好因子与持续时间和非失眠显著相关外，其余睡眠健康因子均显著相关(|RGS|x=0.11-0.51)。更好的睡眠健康通常与较低的精神疾病遗传易感性显著相关(|RGS|F=0.05-0.48)，但这6个睡眠健康因素与不同的精神疾病因素表现出不同的关联模式，特别是在控制睡眠健康因素之间的协方差时。这些结果为睡眠健康结构的遗传可分离性及其与心理健康的关系提供了证据。
Poor sleep is associated with many negative health outcomes, including multiple dimensions of psychopathology. In the past decade, sleep researchers have advocated for focusing on the concept of sleep health as a modifiable health behavior to mitigate or prevent these outcomes. Sleep health dimensions often include sleep efficiency, duration, satisfaction, regularity, timing, and daytime alertness. However, there is no consensus on how to best operationalize sleep health at the phenotypic and genetic levels. In some studies, specific sleep health domains were examined individually, while in others, sleep health domains were examined together (e.g., with an aggregate sleep health score). Here, we compared alternative sleep health factor models using genomic structural equation modeling on summary statistics from previously published genome-wide association studies of self-reported and actigraphic sleep measures with effective sample sizes up to 452,633. Our best-fitting sleep health model had 6 correlated genetic factors pertaining to 6 sleep health domains: circadian preference, efficiency, alertness, duration, noninsomnia, and regularity. All sleep health factors were significantly correlated (|rgs| = 0.11–0.51), except for the circadian preference factor with duration and noninsomnia. Better sleep health was generally significantly associated with lower genetic liability for psychopathology (|rgs| = 0.05–0.48), yet the 6 sleep health factors showed divergent patterns of associations with different psychopathology factors, especially when controlling for covariance among the sleep health factors. These results provide evidence for genetic separability of sleep health constructs and their differentiation with respect to associations with mental health.
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DOI：
10.1080/10705519909540118
发表时间：
1999-01-01
影响因子：
6
作者：
Hu, Li-tze;Bentler, Peter M.
通讯作者：
Bentler, Peter M.
影响因子：
11
作者：
International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Association Studies (OCGAS)
通讯作者：
International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Association Studies (OCGAS)
影响因子：
30.8
作者：
Grotzinger, Andrew D.;Mallard, Travis T.;Akingbuwa, Wonuola A.;Ip, Hill F.;Adams, Mark J.;Lewis, Cathryn M.;McIntosh, Andrew M.;Grove, Jakob;Dalsgaard, Soren;Lesch, Klaus-Peter;Strom, Nora;Meier, Sandra M.;Mattheisen, Manuel;Borglum, Anders D.;Mors, Ole;Breen, Gerome;Lee, Phil H.;Kendler, Kenneth S.;Smoller, Jordan W.;Tucker-Drob, Elliot M.;Nivard, Michel G.
通讯作者：
Nivard, Michel G.
影响因子：
30.8
作者：
Bulik-Sullivan, Brendan K.;Loh, Po-Ru;Finucane, Hilary K.;Ripke, Stephan;Yang, Jian;Patterson, Nick;Daly, Mark J.;Price, Alkes L.;Neale, Benjamin M.
通讯作者：
Neale, Benjamin M.
影响因子：
4.1
作者：
Benham, Grant
通讯作者：
Benham, Grant