Double Dissociation Between Syntactic Gender and Picture Naming Processing: A Brain Stimulation Mapping Study
Double Dissociation Between Syntactic Gender and Picture Naming Processing: A Brain Stimulation Mapping Study
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DOI：
10.1002/hbm.21026
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发表时间：
2011-03-01
影响因子：
4.8
通讯作者：
Duffau, Hugues
中科院分区：
文献类型：
--
作者：
Garbizu Vidorreta, Jose;Garcia, Roser;Duffau, Hugues
句法性别处理的神经基础仍然知之甚少。我们使用电刺激映射在9个右利手清醒的患者在左半球胶质瘤手术期间，研究是否参与命名与句法性别处理的皮质-皮质下结构是共同的或不同的。在法语中，冠词决定语法性别。因此，要求患者执行图片命名任务，并为每张图片提供适当的文章，有刺激和无刺激。皮质刺激引起可重复的句法性别障碍6例，在额下回（3例），并在后中颞回（3例）。有趣的是，在刺激句法部位的过程中没有产生命名障碍，而皮层区域诱导命名障碍时，刺激从未引起语法性别错误。此外，在皮质下水平，刺激尾状核外侧的白色物质会导致三名患者出现性别错误，但没有命名障碍。通过对清醒患者的皮层-皮层下电地形图研究，我们首次证实了：（1）句法性别加工与命名加工之间存在双重分离，支持独立网络模型而非序列理论;（2）左侧额下回，尤其是三角部，以及左侧颞中回后部参与了语法性别加工，（3）白色物质通路的存在，可能是左上级纵束的一个分支，它可能是一个大规模的分布式皮质-皮质下回路，即使与涉及命名（语义和语音）加工的平行子网络相互连接，也可能选择性地辅助句法性别加工。《脑地图》32：331-340，2011年。(C)2010 Wiley-Liss，Inc.
Neural foundations of syntactic gender processing remain poorly understood. We used electrostimulation mapping in nine right-handed awake patients during surgery for a glioma within the left hemisphere, to study whether the cortico-subcortical structures involved in naming versus syntactic gender processing are common or distinct. In French, the article determines the grammatical gender. Thus, the patient was asked to perform a picture naming task and to give the appropriate article for each picture, with and without stimulation. Cortical stimulation elicited reproducible syntactic gender disturbances in six patients, in the inferior frontal gyrus (three cases), and in the posterior middle temporal gyrus (three cases). Interestingly, no naming disorders were generated during stimulation of the syntactic sites, while cortical areas inducing naming disturbances never elicited grammatical gender errors when stimulated. Moreover, at the subcortical level, stimulation of the white matter lateral to the caudate nucleus induced gender errors in three patients, with no naming disorders. Using cortico-subcortical electrical mapping in awake patients, we demonstrate for the first time (1) a double dissociation between syntactic gender and naming processing, supporting independent network model rather than serial theory, (2) the involvement of the left inferior frontal gyrus, especially the pars triangularis, and the posterior left middle temporal gyrus in grammatical gender processing, (3) the existence of white matter pathways, likely a sub-part of the left superior longitudinal fasciculus, underlying a large-scale distributed cortico-subcortical circuit which might selectively sub-serve syntactic gender processing, even if interconnected with parallel sub-networks involved in naming (semantic and phonological) processing. Hum Brain Mapp 32:331-340, 2011. (C) 2010 Wiley-Liss, Inc.