Neurophysiological correlates of memory change in children with fetal alcohol spectrum disorders treated with choline.
Neurophysiological correlates of memory change in children with fetal alcohol spectrum disorders treated with choline.
复制标题
DOI：
10.3389/fpsyg.2022.936019
复制
发表时间：
2022
影响因子：
3.8
通讯作者：
Wozniak, Jeffrey R
中科院分区：
文献类型：
--
作者：
Fuglestad, Anita J;Miller, Neely C;Fink, Birgit A;Boys, Christopher J;Eckerle, Judith K;Georgieff, Michael K;Wozniak, Jeffrey R
产前和产后早期补充胆碱可减少胎儿酒精谱系障碍 (FASD) 动物模型的认知和行为缺陷。在之前发表的一项针对 FASD 儿童补充胆碱的为期 9 个月的临床试验中，我们报告称，出生后胆碱与海马依赖性识别记忆任务表现的改善相关。当前的论文描述了试验完成者的记忆表现的神经生理学相关性。参加补充胆碱临床试验的 FASD 儿童 (N = 24) 被随访了 9 个月。 9步诱发模仿任务（EI）的延迟回忆作为识别记忆的行为测量。通过事件相关电位（ERP）评估记忆的神经生理学相关性。 EI 延迟回忆与幼儿认知记忆中常见的两个 ERP 成分相关：中潜伏期负成分（Nc 幅度；范围：r = −0.41 至 r = −0.44）和正慢波（PSW 曲线下面积；范围：r = −0.45 至 r = −0.63）。试验结束时，胆碱组和安慰剂组之间没有观察到显着的 ERP 差异。尽管样本量小限制了就胆碱对 ERP 的治疗效果得出明确结论的能力，但结果表明 FASD 的记忆表现与潜在的神经生理状态之间存在关系。该试验已注册。1
Prenatal and early postnatal choline supplementation reduces cognitive and behavioral deficits in animal models of Fetal Alcohol Spectrum Disorder (FASD). In a previously published 9-month clinical trial of choline supplementation in children with FASD, we reported that postnatal choline was associated with improved performance on a hippocampal-dependent recognition memory task. The current paper describes the neurophysiological correlates of that memory performance for trial completers. Children with FASD (N = 24) who were enrolled in a clinical trial of choline supplementation were followed for 9 months. Delayed recall on a 9-step elicited imitation task (EI) served as the behavioral measure of recognition memory. Neurophysiological correlates of memory were assessed via event-related potentials (ERP). Delayed recall on EI was correlated with two ERP components commonly associated with recognition memory in young children: middle latency negative component (Nc amplitude; range: r = −0.41 to r = −0.44) and positive slow wave (PSW area under the curve; range: r = −0.45 to r = −0.63). No significant ERP differences were observed between the choline and placebo groups at the conclusion of the trial. Although the small sample size limits the ability to draw clear conclusions about the treatment effect of choline on ERP, the results suggest a relationship between memory performance and underlying neurophysiological status in FASD. This trial was registered.1