CCL2-CCR2 Signaling in Disease Pathogenesis
CCL2-CCR2 Signaling in Disease Pathogenesis
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DOI：
10.2174/1871530315666150316120920
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发表时间：
2015-01-01
影响因子：
1.9
通讯作者：
Heikenwalder, Mathias
中科院分区：
文献类型：
--
作者：
O'Connor, Tracy;Borsig, Lubor;Heikenwalder, Mathias
趋化因子及其受体在控制几种生理和病理过程中的作用仅在最近几年才变得明显。从化学吸引的单一功能，我们对趋化因子受体活化的观点已经转变为影响许多分子和细胞过程的多效性信号传导途径的调节。大量的趋化因子和受体以及因此可能的趋化因子-趋化因子受体相互作用的组合，以及趋化因子和趋化因子受体在特定细胞类型内的表达谱，导致了我们今天所看到的趋化因子受体信号传导的复杂性。趋化因子CCL 2及其主要趋化因子受体CCR 2与几种不同疾病过程的发病机制有关，包括转移期间血管通透性和免疫细胞的吸引、许多不同的神经系统疾病、自身免疫疾病、肥胖症和动脉粥样硬化。在这里，我们回顾了最近的研究结果的作用，CCL 2-CCR 2轴在这些疾病的调节。我们相信，研究只是对趋化因子可以控制什么以及潜在机制是什么有了初步的了解。在不久的将来，肯定会有更多的发现，这些发现将对临床应用产生重大影响。
The role of chemokines and their receptors in controlling several physiological and pathological processes has only become evident in the last couple of years. From a sole function of chemo-attraction, our view on chemokine receptor activation has switched to the regulation of pleiotropic signaling pathways influencing numerous molecular and cellular processes. The large number of chemokines and receptors and hence possible combinations of chemokine-chemokine receptor interactions, as well as the expression profiles of chemokines and chemokine receptors within particular cell types, has contributed to the complexity of chemokine receptor signaling as we see it today. The chemokine CCL2 and its main chemokine receptor CCR2 have been implicated in the pathogenesis of several different disease processes, including vascular permeability and attraction of immune cells during metastasis, a number of different neurological disorders, autoimmune disease, obesity, and atherosclerosis. Here we review recent findings on the role of the CCL2-CCR2 axis in the regulation of these diseases. We believe that research has only gained a first glimpse of what chemokines can control and what the underlying mechanisms are. There is certainly more to be found that will - with high certainty - have strong implications for clinical applications in the near future.