Acute consumption of fish oil improves postprandial VLDL profiles in healthy men aged 50-65 years
Acute consumption of fish oil improves postprandial VLDL profiles in healthy men aged 50-65 years
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DOI：
10.1017/s0007114508143550
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发表时间：
2009-07-14
影响因子：
3.6
通讯作者：
Calder, Philip C.
中科院分区：
文献类型：
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作者：
Burdge, Graham C.;Powell, Jonathan;Calder, Philip C.
膳食补充鱼油诱导血浆脂蛋白的大小和浓度的有益变化，尽管潜在的机制尚不清楚。我们研究了在餐后期间增加单餐中鱼油量对VLDL，LDL和HDL颗粒的大小和浓度的影响。年龄58岁（SD 5）的健康男性（n 11）以随机顺序食用含0.3 g（参考，REF）或2.2 g（高鱼油，HFO）鱼油的等能量混合常量营养素试验餐，并在随后的6小时内收集血液样本。通过NMR光谱法测量血浆脂蛋白的大小和浓度。时间和膳食组成对VLDL有显著的交互作用，但对LDL或HDL、浓度（P=0.036）和粒度（P=0.005）无交互作用。食用HFO餐显著增加VLDL浓度（P
Dietary supplementation with fish oil induces beneficial changes in the size and concentration of plasma lipoproteins, although the underlying mechanism is unclear. We have investigated the effect of increasing the amount of fish oil in a single meal on the size and concentration of VLDL, LDL and HDL particles during the postprandial period. Healthy men aged 58 (SD 5) years (n 11) consumed isoenergetic, mixed macronutrient test meals containing either 0.3 g (reference, REF) or 2.2 g (high fish oil, HFO) fish oil in a randomised order, and blood samples were collected over the following 6h. Plasma lipoprotein size and concentration were measured by NMR spectroscopy. There was a significant interaction effect of time and meal composition on the VLDL, but not on the LDL or HDL, concentration (P=0.036) and particle size (P=0.005). Consuming the HFO meal significantly increased the VLDL concentration (P