BOLD responses reflecting dopaminergic signals in the human ventral tegmental area
BOLD responses reflecting dopaminergic signals in the human ventral tegmental area
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DOI：
10.1126/science.1150605
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发表时间：
2008-02-29
期刊：
影响因子：
56.9
通讯作者：
Cohen, Jonathan D.
中科院分区：
文献类型：
--
作者：
D'Ardenne, Kimberlee;McClure, Samuel M.;Cohen, Jonathan D.
目前的理论假设多巴胺神经元放电编码奖励预测错误。尽管对非人类物种的研究为这一理论提供了直接支持，但人类的功能性磁共振成像（fMRI）研究主要集中在多巴胺神经元靶向的大脑区域[腹侧纹状体（VStr）]，而不是脑干多巴胺能核[腹侧被盖区（VTA）和黑质]。我们使用功能磁共振成像直接成像脑干。当在实验中使用初级奖励时，VTA血氧水平依赖（BOLD）反应反映了正奖励预测误差，而VStr编码了正和负奖励预测误差。当使用货币收益和损失时，VTA BOLD响应反映了由获胜概率调制的正奖励预测误差。我们没有检测到显着的VTA BOLD反应非奖励性事件。
Current theories hypothesize that dopamine neuronal firing encodes reward prediction errors. Although studies in nonhuman species provide direct support for this theory, functional magnetic resonance imaging ( fMRI) studies in humans have focused on brain areas targeted by dopamine neurons [ ventral striatum ( VStr)] rather than on brainstem dopaminergic nuclei [ ventral tegmental area ( VTA) and substantia nigra]. We used fMRI tailored to directly image the brainstem. When primary rewards were used in an experiment, the VTA blood oxygen level - dependent ( BOLD) response reflected a positive reward prediction error, whereas the VStr encoded positive and negative reward prediction errors. When monetary gains and losses were used, VTA BOLD responses reflected positive reward prediction errors modulated by the probability of winning. We detected no significant VTA BOLD response to nonrewarding events.