Prostate histopathology and the chronic prostatitis/chronic pelvic pain syndrome: A prospective biopsy study
Prostate histopathology and the chronic prostatitis/chronic pelvic pain syndrome: A prospective biopsy study
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DOI：
10.1016/s0022-5347(05)68090-1
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发表时间：
1999-12-01
影响因子：
6.6
通讯作者：
Krieger, JN
中科院分区：
文献类型：
--
作者：
True, LD;Berger, RE;Krieger, JN
目的：慢性前列腺炎/慢性盆腔疼痛综合征是一种常见的临床综合征，其特征是下泌尿生殖道症状，特别是会阴或生殖器疼痛，排尿症状，如排尿困难或尿频，以及尿液或前列腺分泌物中没有尿路病原体的性功能障碍。前列腺炎一词是基于这样的假设：前列腺炎症在该综合征的病理生理学中很重要。据我们所知，尚未对有症状病例中前列腺炎症的程度和性质进行系统表征。材料和方法：对 97 名慢性前列腺炎/慢性盆腔疼痛综合征患者的 368 份活组织检查中的前列腺组织病理学进行了表征。结果：仅 33% 的患者检测到前列腺炎症，其中 29% 为轻度（每 I 中白细胞少于 10 个） 毫米。场），4% 具有中度（10 到 200 之间）或重度（超过 200）渗透。 3 例中度炎症患者中，1 例为腺性、1 例为腺周，3 例为间质内白细胞多灶性或弥漫性分布。一些患者的炎症模式超过 I。结论：97 例患者中仅 5% 发现中度或重度炎症，这表明有必要重新评估慢性前列腺炎/慢性盆腔疼痛病理生理学的当前概念。 综合症。
Purpose: The chronic prostatitis/chronic pelvic pain syndrome is a common clinical syndrome characterized by lower genitourinary tract symptoms, particularly pain in the perineum or genitalia, voiding symptoms, such as dysuria or frequency, and sexual dysfunction in the absence of uropathogens in the urine or prostatic secretions. The term prostatitis is based on the presumption that prostatic inflammation is important in the pathophysiology of this syndrome. To our knowledge there has been no systematic characterization of the degree and nature of inflammation in the prostate in symptomatic cases.Materials and Methods: Prostate histopathology in 368 biopsies from 97 patients with the chronic prostatitis/chronic pelvic pain syndrome was characterized..Results: Prostatic inflammation was detected in only 33% of patients, including 29% with mild (less than 10 leukocytes per I mm. field) and 4% with moderate (between 10 and 200) or severe (more than 200)infiltrate. Of the 3 patients with moderate inflammation 1 had glandular, 1 periglandular and 3 multifocal or diffuse distribution of leukocytes in the interstitium Some patients had more than I pattern of inflammation.Conclusions: The finding of moderate or severe inflammation in only 5% of 97 patients argues for the need to reevaluate current concepts of the pathophysiology of the chronic prostatitis/ chronic pelvic pain syndrome.