QUANTITATIVE CHANGES OF CEREBRAL NEOCORTICAL STRUCTURE IN INSULIN-TREATED LONG-TERM STREPTOZOCIN-INDUCED DIABETES IN RATS
QUANTITATIVE CHANGES OF CEREBRAL NEOCORTICAL STRUCTURE IN INSULIN-TREATED LONG-TERM STREPTOZOCIN-INDUCED DIABETES IN RATS
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DOI：
10.2337/diabetes.36.5.597
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发表时间：
1987-05-01
期刊：
影响因子：
7.7
通讯作者：
OSTERBY, R
中科院分区：
文献类型：
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作者：
JAKOBSEN, J;SIDENIUS, P;OSTERBY, R
用形态计量学技术研究了小剂量胰岛素(1IU/d)治疗链脲佐菌素诱导的糖尿病大鼠的脑功能。糖尿病治疗1年后，脑重量略有下降(1350±-)。71对1521+-。55 mg，2P<；0.01)，新皮质体积(498±-)。36比567。+-。40mm3，2p<；0.05)。新皮质神经元显著丢失(38。+-。2.泰晤士报。106对46。+-。3.泰晤士报。106，2P<；01)，新皮质组织的毛细血管网长度不成比例地缩短(405±-)。102对631。+-。47米，2P<；01)，导致扩散距离增加。在这个模型中，脑丢失的机制尚不清楚，但随着扩散路径的延长，血管供应的异常可能起到一定作用。
The brains of rats with streptozocin-induced diabetes treated with a low-dose insulin regimen (1 IU/day) were studied with morphometric techniques. After 1 yr of diabetes, brain weight decreased slightly (1350 .+-. 71 vs. 1521 .+-. 55 mg, 2P < .01) as did the volume of the neocortex (498 .+-. 36 vs. 567 .+-. 40 mm3, 2P < .05). A significant loss of neocortical neurons occurred (38 .+-. 2 .times. 106 vs. 46 .+-. 3 .times. 106, 2P < .01), and the length of the capillary network in the neocortical tissue shortened disproportionately (405 .+-. 102 vs. 631 .+-. 47 m, 2P < .01), leading to increased diffusion distance. The mechanisms underlying cerebral loss in this model are unknown, but abnormalities of the vascular supply with prolongation of the route of diffusion might play a role.