Trends in survival of patients diagnosed with cancers of the brain and nervous system, thyroid, eye, bone, and soft tissues in the Nordic countries 1964-2003 followed up until the end of 2006
Trends in survival of patients diagnosed with cancers of the brain and nervous system, thyroid, eye, bone, and soft tissues in the Nordic countries 1964-2003 followed up until the end of 2006
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DOI：
10.3109/02841861003610200
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发表时间：
2010-06-01
期刊：
影响因子：
3.1
通讯作者：
Klint, Asa
中科院分区：
文献类型：
--
作者：
Bray, Freddie;Engholm, Gerda;Klint, Asa
背景资料。脑癌、甲状腺癌、眼癌、骨癌和软组织癌的诊断按疾病频率、存活率、病因学和治疗前景的异质性进行分类。在这篇论文中，我们考虑了北欧国家患者生存的时间趋势。材料和方法。按年龄标化的发病率和死亡率、5年相对存活率和不同随访期的超额死亡率，以及按国家、性别和5年诊断期列出的特定年龄的5年相对存活率。结果。脑癌发病率一直在上升，但死亡率一直相对稳定，自20世纪70年代初以来，5年生存率一致上升，特别是在年轻患者中。男性患脑癌的五年存活率在45%到50%之间，女性在60%到70%之间，每个北欧人口的额外死亡人数都随着时间的推移而下降。在20世纪60年代和70年代，甲状腺癌的年龄标化发病率一直在上升，尽管此后的趋势有所不同，过去40年来，5年相对存活率增加了20-30个百分点，达到约80%-90%。在丹麦，甲状腺癌的存活率一直较低，特别是在被诊断为60岁以上的患者中，而首次诊断后三个月的额外死亡人数的地理差异较小。随着时间的推移，眼癌的相对生存率从1964-1968年的大约60%上升到1999-2003年的80%，而对于骨肉瘤，发病率保持稳定，死亡率下降，5年生存率略有增加到55%-65%左右。自20世纪60年代以来，软组织肉瘤的发病率和存活率一直在缓慢增加，最近一段时间的存活率变化很小(约65%)。结论。随着时间的推移，存活率发生了一些显著的变化，这可能与不同国家的流行病学和临床因素有关。然而，主要组织学亚型随时间变化的比例可能影响了这里综述的一些癌症形式的生存估计。
Background. Diagnoses of cancer of the brain, thyroid, eye, bone, and soft tissues are categorised by heterogeneity in disease frequency, survival, aetiology and prospects for curative therapy. In this paper, temporal trends in patient survival in the Nordic countries are considered. Material and methods. Age-standardised incidence and mortality rates, 5-year relative survival, and excess mortality rates for varying follow-up periods are presented, as are age-specific 5-year relative survival by country, sex and 5-year diagnostic period. Results. Brain cancer incidence rates have been rising but mortality has been relatively stable, with 5-year survival uniformly increasing from the early-1970s, particularly in younger patients. Five-year survival from brain cancer among men varies between 45% and 50% for men and 60% to 70% in women, with excess deaths decreasing with time in each of the Nordic populations. Age-standardised incidence rates of thyroid cancer have been mainly increasing during the 1960s and 1970s, although trends thereafter diverge, with 5-year relative survival increasing 20-30 percentage points over the last 40 years to around 80-90%. Thyroid cancer survival is consistently lower in Denmark, particularly in patients diagnosed aged over 60, while there is less geographic variation in excess deaths three months beyond initial diagnosis. Relative survival from eye cancer increased with time from approximately 60% in 1964-1968 to 80% 1999-2003, while for bone sarcoma, incidence rates remained stable, mortality rates declined, and 5-year survival increased slightly to around 55-65%. Soft tissue sarcoma incidence and survival have been slowly increasing since the 1960s, with little variation in survival (around 65%) for the most recent period. Conclusions. There have been some notable changes in survival that can be linked to epidemiological and clinical factors in different countries over time. Time-varying proportions of the major histological subtypes might however have affected the survival estimates for a number of the cancer forms reviewed here.