Advancing addiction treatment: what can we learn from animal studies?
Advancing addiction treatment: what can we learn from animal studies?
复制标题
推进成瘾治疗：我们可以从动物研究中学到什么？
DOI：
10.1093/ilar.53.1.4
复制
发表时间：
2012
期刊：
影响因子：
2.5
通讯作者：
Schulz,KalynnM
中科院分区：
文献类型：
--
作者：
Wu,PeterH;Schulz,KalynnM
物质成瘾是一种不适应的行为，其特征是对某种物质(药物)的强迫和不受控制的自我管理。多年的研究表明，成瘾行为是药物、使用者和使用药物的环境之间复杂相互作用的结果；因此，成瘾不能简单地归因于药物的神经生物学作用。然而，尽管成瘾行为明显复杂，但动物模型既提高了对成瘾的理解，也为治疗这种疾病的药物的开发做出了重要贡献。我们简要回顾了最近用于研究药物成瘾的动物模型，以及这些动物模型产生的数据对成瘾障碍临床治疗的贡献。
Substance addiction is a maladaptive behavior characterized by compulsive and uncontrolled self-administration of a substance (drug). Years of research indicate that addictive behavior is the result of complex interactions between the drug, the user, and the environment in which the drug is used; therefore, addiction cannot simply be attributed to the neurobiological actions of a drug. However, despite the obvious complexity of addictive behavior, animal models have both advanced understanding of addiction and contributed importantly to the development of medications to treat this disease. We briefly review recent animal models used to study drug addiction and the contribution of data generated by these animal models for the clinical treatment of addictive disorders.