Influence of predictive information on responses of tonically active neurons in the monkey striatum
Influence of predictive information on responses of tonically active neurons in the monkey striatum
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DOI：
10.1152/jn.1998.80.6.3341
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发表时间：
1998-12-01
影响因子：
2.5
通讯作者：
Legallet, E
中科院分区：
文献类型：
--
作者：
Apicella, P;Ravel, S;Legallet, E
我们研究了对行为意义信号的预期如何影响两只猴子纹状体中紧张性活跃神经元的活动，这两种猴子在两种条件下执行简单的反应时间任务，一种是无提示条件，其中触发刺激在时间上随机发生，另一种是提示条件，其中相同触发之前有指令刺激，作为即将到来的信号的预测信号，引发立即行为反应。两只猴子都受益于指令刺激的存在，减少了它们的反应时间，这表明与无提示试验相比，有提示试验期间预测触发发作的能力有所增强。在无提示条件下，大多数神经元（199/272，73%）在触发刺激开始后表现出阶段性活动减少，而只有 38% 在指令之前对相同刺激做出反应。此外，无提示条件下的触发反应幅度显着高于有提示条件下。百分之五十七的神经元对指令刺激做出反应，而在提示条件下失去对触发反应的神经元中有一半对指令刺激做出了反应。这些发现表明，强直纹状体神经元对运动触发刺激的反应受到预测信息的影响。
We investigated how the expectation of a signal of behavioral significance influences the activity of tonically active neurons in the striatum of two monkeys performing a simple reaction time task under two conditions, an uncued condition in which the trigger stimulus occurred randomly in time and a cued condition in which the same trigger was preceded by an instruction stimulus serving as a predictive signal for the forthcoming signal eliciting an immediate behavioral reaction. Both monkeys benefited from the presence of the instruction stimulus to reduce their reaction time, suggesting an increased ability to predict the trigger onset during cued trials compared with uncued trials. A majority of neurons (199/272, 73%) showed a phasic reduction in activity after the onset of the trigger stimulus in the uncued condition, whereas only 38% responded to the same stimulus when it was preceded by the instruction. Furthermore, magnitudes of trigger responses in the uncued condition were significantly higher than in the cued condition. Fifty-seven percent of the neurons responded to the instruction stimulus, and one-half of the neurons losing their response to the trigger in the cued condition responded to the instruction stimulus. These findings suggest that responses of tonic striatal neurons to a trigger stimulus for movement were influenced by predictive information.