The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertility
The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertility
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DOI：
10.1189/jlb.1005557
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发表时间：
2006-05-01
影响因子：
5.5
通讯作者：
Mantovani, Alberto
中科院分区：
文献类型：
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作者：
Bottazzi, Barbara;Bastone, Antonio;Mantovani, Alberto
长正五聚蛋白3（PTX 3）是一个复杂的多功能蛋白质超家族的成员，其特征在于环状多聚体结构。PTX 3在进化中高度保守，由先天免疫细胞响应促炎信号和Toll样受体接合而产生。PTX 3在体内发挥复杂的非冗余功能，作为抗体的前体，识别微生物，激活补体，促进吞噬细胞识别病原体，因此，在抵抗选定病原体方面发挥非冗余作用。此外，PTX 3在女性生育力中是必不可少的，其作为卵丘富含透明质酸的细胞外基质的组装的节点。因此，原型长五聚蛋白PTX 3是一种多功能的可溶性模式识别受体，作为先天免疫的体液臂的非冗余组分，并参与基质沉积和女性生育力。
The long pentraxin 3 (PTX3) is member of a complex superfamily of multifunctional proteins characterized by a cyclic multimeric structure. PTX3 is highly conserved in evolution and is produced by innate-immunity cells in response to proinflammatory signals and Toll-like receptor engagement. PTX3 plays complex, nonredundant functions in vivo, acting as a predecessor of antibodies, recognizing microbes, activating complement, facilitating pathogen recognition by phagocytes, and hence, playing a nonredundant role in resistance against selected pathogens. In addition, PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. Thus, the prototypic long pentraxin PTX3 is a multifunctional, soluble pattern recognition receptor acting as a nonredundant component of the humoral arm of innate immunity and involved in matrix deposition and female fertility.