Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice
Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice
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DOI：
10.1128/iai.74.4.2423-2427.2006
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发表时间：
2006-04-01
影响因子：
3.1
通讯作者：
Taniguchi, K
中科院分区：
文献类型：
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作者：
Maeno, Y;Nakazawa, S;Taniguchi, K
骨桥蛋白 (OPN) 敲除小鼠（OPN-KO 小鼠）死于 Plasinodium chabaudi chabaudi 感染，但野生型 (WT) 小鼠具有自限性感染。感染后 2 天在 WT 小鼠中检测到 OPN。 OPN-KO 小鼠产生的白细胞介素 12 和γ干扰素的量明显少于 WT 小鼠。这些结果表明 OPN 参与 Th1 介导的针对疟疾感染的免疫。
Osteopontin (OPN) knockout mice (OPN-KO mice) died of Plasinodium chabaudi chabaudi infection, although wild-type (WT) mice had self-limiting infections. OPN was detected in the WT mice at 2 days postinfection. OPN-KO mice produced significantly smaller amounts of interleukin-12 and gamma interferon than WT mice produced. These results suggested that OPN is involved in Th1-mediated immunity against malaria infection.