The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells.
The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells.
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DOI：
10.1084/jem.20081571
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发表时间：
2009-01-16
期刊：
影响因子：
--
通讯作者：
Rincon M
中科院分区：
文献类型：
--
作者：
Dienz O;Eaton SM;Bond JP;Neveu W;Moquin D;Noubade R;Briso EM;Charland C;Leonard WJ;Ciliberto G;Teuscher C;Haynes L;Rincon M
白细胞介素6（IL 6）是由抗原呈递细胞和非造血细胞响应外部刺激而产生的促炎细胞因子。它最初被鉴定为体外B细胞生长因子和浆细胞分化诱导剂，并在体内抗体产生和类别转换中起重要作用。然而，目前尚不清楚IL-6是否直接影响B细胞或通过其他机制发挥作用。我们表明，IL-6是足够的和必要的诱导IL-21的生产幼稚和记忆CD 4 + T细胞后T细胞受体刺激。IL-6在体外促进B细胞抗体产生需要通过CD 4 + T细胞产生IL-21。此外，IL-6与失活流感病毒一起施用增强了病毒特异性抗体的产生，并且重要的是，这种作用依赖于IL-21。因此，IL-6通过增加IL-21的产生来促进CD 4 + T细胞的B细胞辅助能力，从而促进抗体产生。因此，IL-6可能是一种潜在的辅助佐剂，以增强体液免疫。
Interleukin (IL) 6 is a proinflammtory cytokine produced by antigen-presenting cells and nonhematopoietic cells in response to external stimuli. It was initially identified as a B cell growth factor and inducer of plasma cell differentiation in vitro and plays an important role in antibody production and class switching in vivo. However, it is not clear whether IL-6 directly affects B cells or acts through other mechanisms. We show that IL-6 is sufficient and necessary to induce IL-21 production by naive and memory CD4+ T cells upon T cell receptor stimulation. IL-21 production by CD4+ T cells is required for IL-6 to promote B cell antibody production in vitro. Moreover, administration of IL-6 with inactive influenza virus enhances virus-specific antibody production, and importantly, this effect is dependent on IL-21. Thus, IL-6 promotes antibody production by promoting the B cell helper capabilities of CD4+ T cells through increased IL-21 production. IL-6 could therefore be a potential coadjuvant to enhance humoral immunity.
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影响因子：
32.4
作者：
Nurieva, Roza I.;Chung, Yeonseok;Hwang, Daehee;Yang, Xuexian O.;Kang, Hong Soon;Ma, Li;Wang, Yi-Hong;Watowich, Stephanie S.;Jetten, Anton M.;Tian, Qiang;Dong, Chen
通讯作者：
Dong, Chen
影响因子：
3.6
作者：
Diehl, S;Rincón, M
通讯作者：
Rincón, M
影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.
影响因子：
12.3
作者：
Gentleman RC;Carey VJ;Bates DM;Bolstad B;Dettling M;Dudoit S;Ellis B;Gautier L;Ge Y;Gentry J;Hornik K;Hothorn T;Huber W;Iacus S;Irizarry R;Leisch F;Li C;Maechler M;Rossini AJ;Sawitzki G;Smith C;Smyth G;Tierney L;Yang JY;Zhang J
通讯作者：
Zhang J
影响因子：
20.3
作者：
Fornek, JL;Tygrett, LT;Kansas, GS
通讯作者：
Kansas, GS