Studies towards the synthesis of Fipronil® analogues:: improved decarboxylation of α-hydrazonoacid derivatives
Studies towards the synthesis of Fipronil® analogues:: improved decarboxylation of α-hydrazonoacid derivatives
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DOI：
10.1016/s0040-4039(02)01977-9
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发表时间：
2002-11-11
影响因子：
1.8
通讯作者：
Jana, NK
中科院分区：
文献类型：
--
作者：
Ancel, JE;El Kaïm, L;Jana, NK
腙的曼尼希反应与异氰化物的[4+1]环加成反应已被用于合成Fipronil 的氨基吡唑类似物。起始氰腙是在新的实验条件下制备的，以便在氟化溶剂中进行有效的重氮偶联，然后进行新的氰化钠催化脱羧。 (C) 2002 年，爱思唯尔科学有限公司出版。
The Mannich reaction of hydrazones coupled with a [4+1] cycloaddition with isocyanides has been used for the synthesis of aminopyrazole analogues of Fipronil(R). The starting cyanohydrazone was prepared with new experimental conditions for efficient diazonium coupling in fluorinated solvents followed by a new sodium cyanide catalysed decarboxylation. (C) 2002 Published by Elsevier Science Ltd.