Persistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype
Persistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype
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DOI：
10.1016/j.immuni.2012.11.020
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发表时间：
2013-03-21
期刊：
影响因子：
32.4
通讯作者：
Sallusto, Federica
中科院分区：
文献类型：
--
作者：
Baumjohann, Dirk;Preite, Silvia;Sallusto, Federica
滤泡辅助性T细胞（Tfh）为B细胞提供帮助，并且对于建立生殖中心（GC）反应至关重要，包括产生高亲和力抗体和产生记忆B细胞和长寿浆细胞。在这里，我们报告的Tfh细胞反应的幅度是由抗原的量，并直接与GC B细胞反应的幅度。此外，Tfh细胞表型的维持需要GC B细胞持续的抗原刺激。在淋巴细胞减少的情况下，一个强大的和长期的Tfh细胞反应导致旁观者B细胞活化，高丙种球蛋白血症，并产生多和自身反应性抗体。这些数据表明，抗原剂量决定了Tfh细胞应答和GC反应的大小和持续时间，突出了Tfh细胞表型的瞬时性质，并表明Tfh细胞的过度刺激与失调的体液免疫应答的发展之间存在联系。
T follicular helper (Tfh) cells provide help to B cells and are crucial for establishment of germinal center (GC) reactions, including production of high-affinity antibodies and generation of memory B cells and long-lived plasma cells. Here we report that the magnitude of the Tfh cell response was dictated by the amount of antigen and directly correlated with the magnitude of the GC B cell response. In addition, maintenance of the Tfh cell phenotype required sustained antigenic stimulation by GC B cells. In lymphopenic conditions, a strong and prolonged Tfh cell response led to bystander B cell activation, hyper-gammaglobulinemia, and production of poly-and self-reactive antibodies. These data demonstrate that antigen dose determines the size and duration of the Tfh cell response and GC reaction, highlight the transient nature of the Tfh cell phenotype, and suggest a link between overstimulation of Tfh cells and the development of dysregulated humoral immune responses.