Two new beta-class milbemycins from streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties.
Two new beta-class milbemycins from streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties.
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发表时间：
2007
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通讯作者：
W. Xiang;Jidong Wang;Xiangjing Wang;Ji Zhang
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作者：
W. Xiang;Jidong Wang;Xiangjing Wang;Ji Zhang
已从丙城链霉菌中分离和鉴定了两种新的 β 类米尔贝霉素，命名为米尔贝霉素 beta(13) 和 beta(14)。生产菌保藏于中国普通微生物菌种保藏中心（保藏号：CGMCC1734）。根据详细的光谱分析和与报道数据的比较，确定它们的结构分别为米尔贝霉素β(3)和25-乙基米尔贝霉素β(3)的C-27羟基衍生物。米尔倍霉素β(13) 和β(14) 具有有效的杀螨和杀线虫活性。这两种化合物的发现对于理解和完善米尔倍霉素的拟议途径发挥着重要作用。
Two new beta-class milbemycins from Streptomyces bingchenggensis, named milbemycin beta(13) and beta(14), have been isolated and characterized. The producing organism has been deposited at the China General Microbiology Culture Collection Center (Accession No: CGMCC1734). On the basis of detailed spectroscopic analysis and comparison with reported data, their structures were determined to be the hydroxyl derivatives at C-27 of milbemycin beta(3) and 25-ethylmilbemycin beta(3), respectively. Milbemycins beta(13) and beta(14) possess potent acaricidal and nematocidal activity. The discovery of these two compounds plays an important role in understanding and perfecting the proposed pathways of milbemycins.