Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats
Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats
复制标题
DOI：
10.1016/s0306-4522(99)00107-4
复制
发表时间：
1999-01-01
期刊：
影响因子：
3.3
通讯作者：
Masumura, S
中科院分区：
文献类型：
--
作者：
Gamoh, S;Hashimoto, M;Masumura, S
Wistar大鼠连续三代以缺乏鱼油的饲料喂养。将第3代幼龄(5周龄)雄性大鼠随机分为两组。10周以上，一组口服溶解于5%阿拉伯树胶溶液中的二十二碳六烯酸，剂量为300 mg/kg/d；另一组仅给予等量的赋形剂。开始给药5周后，用部分(8个中的4个)诱饵八臂径向迷宫测试大鼠与参考记忆和工作记忆两种记忆相关的学习能力。参考记忆是应该保留到下一次试验的信息。工作记忆是在短时间内消失的信息。进入无诱饵手臂和重复进入来访手臂分别被定义为参考记忆错误和工作记忆错误。服用二十二碳六烯酸10周可显著减少参考记忆错误的数量，但不影响工作记忆错误的数量，并显著增加海马区和大脑皮层的二十二碳六烯酸含量和二十二碳六烯酸/花生四烯酸的比率。这些结果表明，长期服用二十二碳六烯酸有助于提高与参考记忆相关的学习能力，海马和/或大脑皮层的二十二碳六烯酸/花生四烯酸比值可能是学习能力的一个指标。(C)1999年IBRO。爱思唯尔科学有限公司出版。
Wistar rats were fed a fish oil-deficient diet through three generations. The young (five-week-old) male rats of the third generation were randomly divided into two groups. Over 10 weeks, one group was perorally administered docosahexaenoic acid dissolved in 5% gum Arabic solution at 300 mg/kg/day; the other group received a similar volume of vehicle alone. Five weeks after starting the administration, the rats were tested for learning ability related to two types of memory, reference memory and working memory, with the partially (four of eight) baited eight-arm radial maze. Reference memory is information that should be retained until the next trial. Working memory is information that disappears in a short time. Entries into unbaited arms and repeated entries into visited arms were defined as reference memory errors and working memory errors, respectively. Docosahexaenoic acid administration over 10 weeks significantly reduced the number of reference memory errors, without affecting the number of working memory errors, and significantly increased the docosahexaenoic acid content and the docosahexaenoic acid/arachidonic acid ratio in both the hippocampus and the cerebral cortex. In addition, the ratio demonstrated a significantly negative correlation with the number of reference memory errors.These results suggest that chronic administration of docosahexaenoic acid is conducive to the improvement of reference memory-related learning ability, and that the docosahexaenoic acid/arachidonic acid ratio in the hippocampus or the cerebral cortex, or both, may be an indicator of learning ability. (C) 1999 IBRO. Published by Elsevier Science Ltd.