Multifunctional polymer vesicles for ultrasensitive magnetic resonance imaging and drug delivery
Multifunctional polymer vesicles for ultrasensitive magnetic resonance imaging and drug delivery
复制标题
用于超灵敏磁共振成像和药物输送的多功能聚合物囊泡
DOI：
10.1039/c2jm31891a
复制
发表时间：
2012-01-01
影响因子：
--
通讯作者：
Du, Jianzhong
中科院分区：
文献类型：
--
作者：
Ren, Tianbin;Liu, Qiuming;Du, Jianzhong
本文合成了一类新型的嵌段共聚物聚环氧乙烷-嵌段-聚（丙烯酸叔丁酯-统计丙烯酸）[PEO-b-P（AA-stat-tBA）]，它可以在各种条件下自组装成尺寸可调的聚合物囊泡。生物相容性和亲水性PEO链形成囊泡冠，而PAA-stat-PtBA链形成膜。超顺磁性氧化铁纳米粒子（SPION）的聚合物囊泡的膜内原位生成的纳米沉淀。采用1H NMR、GPC、DLS、TGA、VSM和TEM等方法对嵌段共聚物、聚合物囊泡和Fe 3 O 4修饰的磁性聚合物囊泡的结构和性能进行了表征。水分散性，生物相容性，药物可输送和超顺磁性聚合物囊泡表现出优异的胶体稳定性在一系列的pH值条件和非常高的T2弛豫，表现出超灵敏度的磁共振成像和有前途的潜在应用在纳米医学。
Presented in this article is the synthesis of a new class of block copolymer, poly(ethylene oxide)-block-poly(tert-butyl acrylate-stat-acrylic acid) [PEO-b-P(AA-stat-tBA)], which can self-assemble into polymer vesicles with tuneable sizes at various conditions. The biocompatible and hydrophilic PEO chains form the vesicle coronas, while the PAA-stat-PtBA chains form the membrane. Superparamagnetic iron oxide nanoparticles (SPIONs) were generated in situ within the membrane of the polymer vesicles by nanoprecipitation. 1H NMR, GPC, DLS, TGA, VSM and TEM were employed to characterize the structure and properties of the block copolymer, polymer vesicles and Fe3O4-decorated magnetic polymer vesicles. The water-dispersible, biocompatible, drug deliverable and superparamagnetic polymer vesicles exhibited excellent colloidal stability at a range of pH conditions and very high T2 relaxivity, demonstrating ultra-sensitivity for magnetic resonance imaging and promising potential applications in nanomedicine.