Ganotheaecolin A, a Neurotrophic Conjugated Ergosterol with a Naphtho[1,8-ef]azulene Scaffold from Ganoderma theaecolum
Ganotheaecolin A, a Neurotrophic Conjugated Ergosterol with a Naphtho[1,8-ef]azulene Scaffold from Ganoderma theaecolum
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DOI：
10.1021/acs.orglett.7b00012
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发表时间：
2017-02-03
期刊：
影响因子：
5.2
通讯作者：
Cheng, Yong-Xian
中科院分区：
文献类型：
--
作者：
Luo, Qi;Yang, Zhu-Liang;Cheng, Yong-Xian
灵芝Aecolin A(1)是从灵芝的子实体中分离得到的一种新的麦角甾醇，具有稀有的萘并[1，8-ef]天青烯环系。其结构由波谱数据和计算方法确定。化合物1是典型的由Wagner-Meerwein重排形成的6/6/7/5融合碳骨架麦角甾醇，对其合理的生物合成途径进行了简要讨论。最后，用PC12细胞检测1的神经营养活性。
Ganotheaecolin A (1), a novel ergosterol with a rare naphtho[1,8-ef]azulene ring system, was isolated from the fruiting bodies of Ganoderma theaecolum. Its structure was determined by spectroscopic data and computational methods. Compound 1 represents a 6/6/7/5-fused carbon skeletal ergosterol typically formed by Wagner-Meerwein rearrangement, whose plausible biosynthetic pathway was briefly discussed. Finally, the neurotrophic activity of 1 was examined using PC12 cells.