Genetic detection of quinolone resistance in Haemophilus parainfluenzae: Mutations in the quinolone resistance-determining regions of gyrA and parC.

Genetic detection of quinolone resistance in Haemophilus parainfluenzae: Mutations in the quinolone resistance-determining regions of gyrA and parC.
复制标题

副流感嗜血杆菌喹诺酮耐药性的基因检测：gyrA 和 parC 喹诺酮耐药决定区的突变。

DOI：
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发表时间：
2010
期刊：
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
影响因子：
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通讯作者：
R. Tsang
R. Tsang
中科院分区：
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文献类型：
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作者：
D. Law;M. Shuel;S. Bekal;E. Bryce;R. Tsang

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对喹诺酮敏感和喹诺酮耐药的副流感嗜血杆菌菌株的 gyrA 和 parC 的喹诺酮耐药决定区进行了扩增和测序。与流感嗜血杆菌类似，副流感嗜血杆菌对喹诺酮类药物的耐药性与 gyrA 和 parC 喹诺酮类耐药决定区的突变有关。本研究讨论了这一发现的重要性。
The quinolone resistance-determining regions of gyrA and parC of both quinolone-sensitive and quinolone-resistant Haemophilus parainfluenzae strains were amplified and sequenced. Similar to Haemophilus influenzae, resistance to quinolones in H parainfluenzae is associated with mutations in the quinolone resistance-determining regions of both gyrA and parC. The present study discusses the importance of this finding.