Vagal afferents mediate the feeding response to mercaptoacetate but not to the beta (3) adrenergic receptor agonist CL 316,243.
Vagal afferents mediate the feeding response to mercaptoacetate but not to the beta (3) adrenergic receptor agonist CL 316,243.
复制标题
迷走神经传入介导对巯基乙酸盐的摄食反应，但不介导对 β (3) 肾上腺素能受体激动剂 CL 316,243 的摄食反应。
DOI：
10.1016/j.neulet.2006.10.034
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发表时间：
2007
影响因子：
2.5
通讯作者：
Leonhardt,Monika
中科院分区：
文献类型：
--
作者：
Brandt,Karsten;Arnold,Myrtha;Geary,Nori;Langhans,Wolfgang;Leonhardt,Monika
为了评估膈下迷走神经传入神经对外周给予高选择性 β3-肾上腺素能受体激动剂 CL 316,243 (CL) 的厌食反应中的作用，我们测试了腹膜内 (IP) 注射 CL 抑制膈下迷走神经传入神经阻滞 (SDA, n=13) 或假手术 (SHAM, n=13) 大鼠摄食的能力。 10、100和1000ng/kg CL剂量显着减少了SHAM和SDA大鼠的摄食量，其量在统计上相似。 IP 注射一小时后，每剂 CL 还显着增加了游离脂肪酸和 β-羟基丁酸（肝脂肪酸氧化 (FAO) 指标）的血浆浓度，而注射后 6 小时，只有两次最高 CL 剂量增加了血浆 β-羟基丁酸。相比之下，外周给予FAO抑制剂巯基乙酸盐（MA，45.6mg/kg IP）刺激SHAM大鼠的摄食，但不刺激SDA大鼠的摄食，这扩展了先前的数据，表明迷走神经传入在FAO抑制的摄食刺激作用中具有必要的作用。我们得出的结论是，膈下迷走神经传入对于 MA 的摄食刺激作用至关重要，但对于外周 CL 的厌食作用不是必需的，并且 CL 诱导的肝脏 FFA 增加对于其摄食抑制作用并不是必需的。
To evaluate the role of subdiaphragmatic vagal afferents in the anorectic response to peripheral administration of the highly selective β3-adrenergic receptor agonist CL 316,243 (CL), we tested the ability of intraperitoneal (IP) injections of CL to inhibit feeding in rats with subdiaphragmatic vagal deafferentation (SDA, n=13) or sham surgeries (SHAM, n=13). Doses of 10, 100 and 1000ng/kg CL significantly reduced feeding by statistically similar amounts in SHAM and SDA rats. One hour after IP injection, each dose of CL also significantly increased plasma concentrations of free fatty acids and β-hydroxybutyrate, an indicator of hepatic fatty acid oxidation (FAO), whereas 6h after injection only the two highest CL doses increased plasma β-hydroxybutyrate. In contrast, peripheral administration of the FAO inhibitor mercaptoacetate (MA, 45.6mg/kg IP) stimulated feeding in SHAM but not in SDA rats, extending previous data suggesting a necessary role of vagal afferents in the feeding-stimulatory effect of FAO inhibition. We conclude that subdiaphragmatic vagal afferents are essential for the feeding-stimulatory action of MA but not for the anorectic action of peripheral CL and that CL-induced increase in hepatic FAO is not essential for its feeding-inhibitory effect.