Residual injury in the spinal cord after treatment with X rays or neutrons.
Residual injury in the spinal cord after treatment with X rays or neutrons.
复制标题
X 射线或中子治疗后脊髓残留损伤。
DOI：
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发表时间：
1982
影响因子：
2.6
通讯作者：
P. Warren
中科院分区：
文献类型：
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作者：
S. Hornsey;R. Myers;P. Warren
X射线或中子照射后100天脊髓的残留损伤通过第二次放射剂量的减少来测量，所述第二次放射剂量是产生神经损伤所需的，所述神经损伤通过在照射后第一年内共济失调的发展来评估。在单次X射线剂量的25%或50%的X射线剂量后观察到5-10%的残留损伤，这在50%的动物中产生共济失调（ED 50），但如果X射线剂量是ED 50剂量的75%，则观察到30%的残留损伤。ED 50中子剂量的25%和50%的中子剂量给出了与等效X射线剂量后观察到的相同水平的残留损伤，表明对于这种类型的损伤，X射线或中子后残留损伤的脱落相似。在一定剂量的X射线后，观察到血管相关损伤的残留损伤多于胶质细胞损失相关损伤。然而，如果残留损伤以预激剂量引起的相关血管或神经胶质细胞损伤表示，则对于神经胶质和血管相关损伤，观察到原发性损伤和残留损伤之间的相同关系。
Residual injury in the spinal cord 100 days after X rays or neutrons was measured by the reduction in dose of a second radiation required to produce nerve damage assessed by the development of ataxia within the first post-irradiation year. Between 5-10% residual damage was observed after X-ray doses of 25% or 50% of the single X-ray dose which produced ataxia in 50% of animals (ED50), but 30% residual injury was observed if the X-ray dose was 75% of the ED50 dose. Neutron doses of 25% and 50% of the ED50 neutron dose gave the same level of residual injury as observed after equivalent X-ray doses, indicating that for this type of damage the shedding of residual damage was similar after X rays or neutrons. More residual damage is observed after a dose of X rays for vascular related damage than for damage associated with glial cell loss. However, if residual damage is expressed in terms of the relevant vascular or glial cell damage caused by the priming dose the same relationship between primary damage and residual damage is seen for both glial and vascular related damage.