INFLUENCE OF HEART-RATE ON MORTALITY AMONG PERSONS WITH HYPERTENSION - THE FRAMINGHAM-STUDY
INFLUENCE OF HEART-RATE ON MORTALITY AMONG PERSONS WITH HYPERTENSION - THE FRAMINGHAM-STUDY
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DOI：
10.1016/0002-8703(93)90128-v
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发表时间：
1993-04-01
影响因子：
4.8
通讯作者：
DAGOSTINO, RB
中科院分区：
文献类型：
--
作者：
GILLMAN, MW;KANNEL, WB;DAGOSTINO, RB
先前的研究表明，心率与全因死亡率和心血管死亡率之间存在正相关。然而，这些关系尚未在高血压患者中进行研究。我们使用Frachial研究的36年随访数据，对4530例年龄在35 - 74岁之间的受试者进行了评估，这些受试者的收缩压≥140 mm Hg或舒张压≥90 mm Hg，且未接受降压药物治疗。我们使用汇总逻辑回归来计算两年期死亡率。调整年龄和收缩压水平后，心率每增加40次/分的优势比和95%置信区间为：全因死亡率，男性2.18（1.68，2.83），女性2.14（1.59，2.88）;心血管死亡率，男性1.68（1.19，2.37），女性1.70（1.08，2.67）。排除测量心率后前2年或4年的结果并没有实质性改变结果，这表明心率加快不仅仅是预先存在疾病的指标。因此，心率可能是高血压患者心血管死亡的独立危险因素。
Previous studies have shown positive associations between heart rate and both all-cause and cardiovascular mortality. These relationships, however, have not been investigated in persons with hypertension. Using 36-year follow-up data from the Framingham Study, we evaluated from 4530 subjects, aged 35 to 74, whose blood pressures were ≥140 mm Hg systolic or ≥90 mm Hg diastolic and who were not treated with antihypertensive medication. We used pooled logistic regression to calculate biennial mortality rates. Odds ratios and 95% confidence intervals for each increment in heart rate of 40 beats/min, adjusted for age and systolic blood pressure level, were:for all-cause mortality, 2.18 (1.68, 2.83) for men and 2.14 (1.59, 2.88) for women; andfor cardiovascular mortality, 1.68 (1.19, 2.37) for men and 1.70 (1.08, 2.67) for women. Exclusion of outcomes in the first 2 or 4 years after measurement of heart rate did not materially change the results, which suggests that rapid heart is not merely an indicator of preexisting illness. Therefore heart rate may be an independent risk factor for cardiovascular death in persons with hypertension.