Variation of human amygdala response during threatening stimuli as a function of 5'HTTLPR genotype and personality style
Variation of human amygdala response during threatening stimuli as a function of 5'HTTLPR genotype and personality style
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DOI：
10.1016/j.biopsych.2005.02.031
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发表时间：
2005-06-15
影响因子：
10.6
通讯作者：
Scarabino, T
中科院分区：
文献类型：
--
作者：
Bertolino, A;Arciero, G;Scarabino, T
背景：在大脑中，恐惧刺激的处理涉及杏仁核，其活动的可变性与遗传因素以及情绪显著性有关。本研究的目的是探讨人格风格与杏仁核反应变异性的相关性。我们研究了两组健康受试者（每组14人），他们将恐惧刺激的显著性归因于不同的认知风格：所谓的恐惧症倾向的受试者夸大潜在的环境威胁，而所谓的饮食失调倾向的受试者往往很少以恐惧为中心。两组在执行威胁性刺激知觉任务时进行了功能磁共振成像（fMRI）检查，并对血清素转运体的5'可变数串联重复序列（VNTR）多态性基因型进行了匹配。fMRI结果显示，恐惧症倾向的结果表明，恐惧症倾向的受试者比饮食失调倾向的受试者选择性地招募杏仁核的程度更大。杏仁核的活动也可以由人格风格和5 -羟色胺转运体的基因型独立预测。此外，在工作记忆任务中的大脑活动并没有将两组区分开来。本研究的结果表明，人格风格的各个方面根植于与环境信息处理相关的恐惧回路的生物反应。
Background: In the brain, processing of fearful stimuli engages the amygdala, and the variability of its activity is associated with genetic factors as well as with emotional salience. The objective of this study was to explore the relevance of personality style for variability of amygdala response.Methods. We studied two groups (n = 14 in each group) of healthy subjects categorized by contrasting cognitive styles with which they attribute salience to fearful stimuli: so-called phobic prone subjects who exaggerate potential environmental threat versus so-called eating disorders prone subjects who tend to be much, less centered around fear. The two groups underwent functional magnetic resonance imaging (fMRI) at 3T during performance of a perceptual task of threatening stimuli and they were also matched for the genotype of the 5'variable number tandem repeat (VNTR) polymorphism in the serotonin transporterResults. The fMRI results indicated that phobic prone results indicated that phobic prone subjects selectively recruit the amygdala to a larger extent than eating disorders prone subjects. Activity in the amygdala was also independently predicted by personality style and genotype of the serotonin transporter. Moreover, brain activity during a working memory task did not differentiate the two groups.Conclusions. The results of the present study suggest that aspects of personality style are rooted in biological responses of the fear circuitry associated with processing of environmental information.