Ascorbic acid intake and oxalate synthesis.
Ascorbic acid intake and oxalate synthesis.
复制标题
DOI：
10.1007/s00240-016-0868-7
复制
发表时间：
2016-08
期刊：
影响因子：
3.1
通讯作者：
Holmes RP
中科院分区：
文献类型：
--
作者：
Knight J;Madduma-Liyanage K;Mobley JA;Assimos DG;Holmes RP
人体每天约有60毫克抗坏血酸（AA）在体内分解，必须通过女性70毫克和男性90毫克的膳食摄入量来替代，以维持最佳健康和AA体内平衡。AA的分解是非酶促的，并导致草酸盐形成。形成的草酸盐的确切量一直难以确定，主要是由于用于此类研究的健康人体组织的有限可用性以及难以测量AA及其分解产物。60 mg AA分解为草酸可能导致每天形成高达30 mg草酸。这超过了我们估计的每天10 - 25 mg草酸盐的内源性产生，表明存在不形成草酸盐的降解途径。在这篇综述中，我们研究什么是已知的AA代谢途径和草酸盐的形式。我们进一步确定如何填补我们知识的空白，以更精确地确定AA分解对人类草酸盐产生的贡献。使用AA的稳定同位素来直接评估维生素向草酸盐的转化应该有助于填补这一空白。
In humans approximately 60 mg of ascorbic acid (AA) breaks down in the body each day and has to be replaced by a dietary intake of 70 mg in females and 90 mg in males to maintain optimal health and AA homeostasis. The breakdown of AA is non-enzymatic and results in oxalate formation. The exact amount of oxalate formed has been difficult to ascertain primarily due to the limited availability of healthy human tissue for such research and the difficulty in measuring AA and its breakdown products. The breakdown of 60 mg of AA to oxalate could potentially result in the formation of up to 30 mg oxalate per day. This exceeds our estimates of the endogenous production of 10 – 25 mg oxalate per day, indicating that degradative pathways that do not form oxalate exist. In this review we examine what is known about the pathways of AA metabolism and how oxalate forms. We further identify how gaps in our knowledge may be filled to more precisely determine the contribution of AA breakdown to oxalate production in humans. The use of stable isotopes of AA to directly assess the conversion of vitamin to oxalate should help fill this void.