Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers
Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers
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DOI：
10.1093/sleep/30.9.1145
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发表时间：
2007-09-01
期刊：
影响因子：
5.6
通讯作者：
Mullington, Janet M.
中科院分区：
文献类型：
--
作者：
Haack, Monika;Sanchez, Elsa;Mullington, Janet M.
内容：睡眠障碍，疼痛和炎症共同发生在各种医疗条件下，但他们的相互关系知之甚少。目的：我们调查的影响，减少睡眠时间（约50%）至4小时/晚，在10天内，外周循环炎症介质。此外，我们测试的预测，炎症的程度是定量相关的疼痛增加的程度，在响应延长sleep restriction.Design：随机，16天的对照实验室研究进行GCRC.Methods：18名志愿者被随机分配到12天的睡眠8小时/晚或4小时/晚。参与者在整个实验日评估情绪和疼痛症状。结果：检测各组大鼠血浆白细胞介素（IL）-6、血清C反应蛋白（CRP）、血浆可溶性肿瘤坏死因子受体p55水平（sTNF-R p55）、前列腺素（PG）代谢物D2和E2的尿水平、疼痛和疲劳的主观评估。IL-6水平在4 h睡眠状态下高于8h睡眠状态（P
Context: Sleep disturbances, pain, and inflammation co-occur in various medical conditions, but their interrelationships are poorly understood.Objective: We investigated the effects of reduced sleep duration (by approximately 50%) to 4 h/night across 10 days, on peripherally circulating inflammatory mediators. In addition, we tested the prediction that degree of inflammation is quantitatively related to the extent to which pain is increased in response to prolonged sleep restriction.Design: Randomized, 16 day controlled in-laboratory study conducted in GCRC.Methods: Eighteen volunteers were randomly assigned to either 12 days of sleeping 8 h/night or 4 h/night. Participants rated mood and pain symptoms throughout experimental days. Urine was collected and blood was drawn frequently on the baseline day and after the 10th experimental day for 25 hours.Outcome Measures: Levels of plasma interleukin (IL)-6, serum C-reactive protein (CRP), plasma soluble tumor necrosis factor receptor p55 (sTNF-R p55), urinary levels of prostaglandin (PG) metabolites D2 and E2, subjective assessment of pain and tiredness-fatigue.Results: IL-6 levels were elevated in the 4-h sleep condition over the 8-h sleep condition (P