Public activities preceding the onset of acute respiratory infection syndromes in adults in England - implications for the use of social distancing to control pandemic respiratory infections.
Public activities preceding the onset of acute respiratory infection syndromes in adults in England - implications for the use of social distancing to control pandemic respiratory infections.
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DOI：
10.12688/wellcomeopenres.15795.1
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发表时间：
2020-01-01
影响因子：
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通讯作者：
Fragaszy, Ellen B
中科院分区：
文献类型：
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作者：
Hayward, Andrew C;Beale, Sarah;Fragaszy, Ellen B
背景：社交距离措施可能会减少新出现的呼吸道感染的传播，但是，关于暴露在拥挤的地方如何影响急性呼吸道感染的风险的经验数据很少。方法：我们使用社区队列中的病例交叉设计来比较感染发作前一周和基线期间自我报告的活动测量值。该设计消除了非时变混杂因素的影响。通过排除圣诞节期间的疾病和季节性调整来解决随时间变化的混杂因素。结果：626 名参与者获得了 1005 种疾病发生前一周和基线前一周的配对数据。前一周每增加一天进行以下活动都与疾病发作相关： 与感冒的人（家庭成员除外）在一个房间里呆上五分钟以上（季节性调整后的 OR 1·15，p=0·003）；使用地铁（1·31，p=0·036）；使用超市 (1·32, p
Background: Social distancing measures may reduce the spread of emerging respiratory infections however, there is little empirical data on how exposure to crowded places affects risk of acute respiratory infection. Methods: We used a case-crossover design nested in a community cohort to compare self-reported measures of activities during the week before infection onset and baseline periods. The design eliminates the effect of non-time-varying confounders. Time-varying confounders were addressed by exclusion of illnesses around the Christmas period and seasonal adjustment. Results: 626 participants had paired data from the week before 1005 illnesses and the week before baseline. Each additional day of undertaking the following activities in the prior week was associated with illness onset: Spending more than five minutes in a room with someone (other than a household member) who has a cold (Seasonally adjusted OR 1·15, p=0·003); use of underground trains (1·31, p=0·036); use of supermarkets (1·32, p