Cancer Clocks Out for Lunch: Disruption of Circadian Rhythm and Metabolic Oscillation in Cancer.
Cancer Clocks Out for Lunch: Disruption of Circadian Rhythm and Metabolic Oscillation in Cancer.
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DOI：
10.3389/fcell.2016.00062
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发表时间：
2016
影响因子：
5.5
通讯作者：
Altman BJ
中科院分区：
文献类型：
--
作者：
Altman BJ
昼夜节律是大多数真核生物和许多原核生物中存在的 24 小时振荡，使活动与昼夜周期同步。它们是有机体和细胞生理学的一个基本特征，协调生物学中研究的许多代谢、生物合成和信号转导途径。昼夜节律的分子机制受到信号转导和基因转录以及代谢反馈的控制。昼夜节律在癌细胞发育和存活中的作用尚不清楚，但正如本综述将讨论的那样，积累的研究表明，在常见致癌改变下游的许多人类癌症中，昼夜节律可能被改变或破坏。因此，对癌症遗传和代谢改变的全面了解必须考虑到潜在的昼夜节律扰动，因为这种扰乱本身将影响癌细胞与其未转化的邻居相比基因表达和代谢的改变。更好地了解正常细胞和癌细胞生理学中的这些昼夜节律变化非常重要，以便有可能设计治疗方式来利用这一见解。
Circadian rhythms are 24-h oscillations present in most eukaryotes and many prokaryotes that synchronize activity to the day-night cycle. They are an essential feature of organismal and cell physiology that coordinate many of the metabolic, biosynthetic, and signal transduction pathways studied in biology. The molecular mechanism of circadian rhythm is controlled both by signal transduction and gene transcription as well as by metabolic feedback. The role of circadian rhythm in cancer cell development and survival is still not well understood, but as will be discussed in this Review, accumulated research suggests that circadian rhythm may be altered or disrupted in many human cancers downstream of common oncogenic alterations. Thus, a complete understanding of the genetic and metabolic alterations in cancer must take potential circadian rhythm perturbations into account, as this disruption itself will influence how gene expression and metabolism are altered in the cancer cell compared to its non-transformed neighbor. It will be important to better understand these circadian changes in both normal and cancer cell physiology to potentially design treatment modalities to exploit this insight.