Photoacoustic imaging of early inflammatory response using gold nanorods
Photoacoustic imaging of early inflammatory response using gold nanorods
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DOI：
10.1063/1.2743752
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发表时间：
2007-05-28
影响因子：
4
通讯作者：
Kaplan, Mariana J.
中科院分区：
文献类型：
--
作者：
Kim, Kang;Huang, Sheng-Wen;Kaplan, Mariana J.
金纳米棒在近红外波段具有异常强的吸收，这可用于纳米胶体的光学成像。利用生物共轭金纳米棒对炎症反应进行光声成像的可行性得到了证实。为了靶向受刺激的细胞，金纳米棒与抗细胞间黏附分子 - 1（ICAM - 1）结合，该分子可与过度表达ICAM - 1的细胞表面结合。使用高频换能器对用生物共轭金纳米棒标记的单层受刺激内皮细胞进行扫描。光声图像能区分炎症细胞和对照细胞，且与荧光图像吻合良好。这项技术可能有助于识别关键的炎症部位，比如血管。（C）2007美国物理学会
Gold nanorods have unusually strong absorption in near infrared, which can be utilized for an optical imaging with nanocolloids. The feasibility of photoacoustic imaging of inflammatory responses using bioconjugated gold nanorods is demonstrated. To target the stimulated cells, gold nanorods were conjugated to anti-intercellular adhesion molecule-1 (ICAM-1) which binds to cell surfaces over expressing ICAM-1. A monolayer of stimulated endothelial cells labeled with bioconjugated gold nanorods was scanned using a high frequency transducer. Photoacoustic images differentiated inflamed cells from control cells and matched well with fluorescence images. This technology may permit identification of critical inflammation sites such as blood vessels. (C) 2007 American Institute of Physics.