Forced Dissociation of Activity Entrained to T Cycles of Food Access in Rats with Suprachiasmatic Lesions
Forced Dissociation of Activity Entrained to T Cycles of Food Access in Rats with Suprachiasmatic Lesions
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视交叉上病变大鼠食物获取 T 周期所伴随的活动的强制解离
DOI：
10.1177/074873048900400406
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发表时间：
1989
影响因子：
3.5
通讯作者：
F. Stephan
中科院分区：
文献类型：
--
作者：
F. Stephan
研究了视交叉上损害的大鼠每天进行两次食物获取的预期轮跑的能力。在23.75小时和24小时的用餐时间表的存在下，七只大鼠中的两只连续多天都进行活动，而其他大鼠则反复将活动从一个时间表转移到另一个时间表。第二组大鼠维持25小时和26小时的进餐时间表。九只大鼠中的一只表现出对两种时间表的长期夹带（即，强迫分离）。在其他大鼠中，抗癫痫活动（AA）在每个时间表上反复增加和减少。在这两个实验中，AA的领先时间表增加时，两餐之间的间隔约为5小时或更少，AA的尾随时间表减少或停止。AA的变化也很常见，当两餐之间的间隔为11和16 hr.The结果是一致的假设，夹带AA定期食物访问介导的至少两个相互耦合的昼夜节律起搏器。当起搏器接近同相或反相时，这些假定的起搏器之间的相互作用似乎最强。
The ability of rats with suprachiasmatic lesions to entrain anticipatory wheel run ning to two food access times per day was investigated. In the presence of meal schedules with periods of 23.75 hr and 24 hr, two of seven rats entrained activity to both for many consecutive days, while other rats repeatedly shifted activity from one schedule to the other. A second group of rats was maintained on 25-hr and 26-hr meal schedules. One of nine rats showed prolonged entrainment to both schedules (i.e., forced dissociation). In the other rats, antici patory activity (AA) waxed and waned repeatedly on each schedule. In both experiments, AA to the leading schedule increased when the interval between meals was about 5 hr or less, and AA to the trailing schedule diminished or ceased. Changes in AA were also common when the interval between meals was between 11 and 16 hr. The results are consistent with the hypoth esis that entrainment of AA to periodic food access is mediated by at least two mutually coupled circadian pacemakers. Interactions between these putative pacemakers appear to be strongest when the pacemakers are nearly in phase or in antiphase.