Role of Dendritic Cells in Inflammation and Loss of Tolerance in the Elderly.
Role of Dendritic Cells in Inflammation and Loss of Tolerance in the Elderly.
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DOI：
10.3389/fimmu.2017.00896
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发表时间：
2017
影响因子：
7.3
通讯作者：
Gupta S
中科院分区：
文献类型：
--
作者：
Agrawal A;Agrawal S;Gupta S
树突状细胞(DC)在促进与年龄相关的适应性免疫应答进行性下降、耐受性丧失和慢性炎症的发展中起着重要作用。在老年人中，DC分泌更多的促炎细胞因子，而降低抗炎和免疫调节细胞因子的水平。这可能会导致慢性炎症和衰老中的耐受性丧失。衰老的树突状细胞对自身抗原的免疫反应也增强，进一步导致炎症和耐受性丧失。I型和III型干扰素等天然保护性细胞因子的分泌减少，DC在老年气道重塑和炎症中的作用也受到影响。此外，DC启动T细胞反应的能力似乎也受到了影响。总体而言，DC功能的这些变化导致了老年人的免疫功能障碍和炎症。本综述仅关注人类DC功能随年龄的变化。
Dendritic cells (DCs) play an important role in advancing age-associated progressive decline in adaptive immune responses, loss of tolerance, and development of chronic inflammation. In aged humans, DCs secrete increased levels of pro-inflammatory cytokines and decreased levels of anti-inflammatory and immune-regulatory cytokines. This may contribute to both chronic inflammation and loss of tolerance in aging. Aged DCs also display increased immune response against self-antigens contributing further to both inflammation and loss of tolerance. The secretion of innate protective cytokines such as type I and III interferons is decreased, and the function of DCs in airway remodeling and inflammation in aged is also compromised. Furthermore, the capacity of DCs to prime T cell responses also seems to be affected. Collectively, these changes in DC functions contribute to the immune dysfunction and inflammation in the elderly. This review only focuses on age-associated changes in DC function in humans.