A prospective study of dietary fiber types and symptomatic diverticular disease in men
A prospective study of dietary fiber types and symptomatic diverticular disease in men
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DOI：
10.1093/jn/128.4.714
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发表时间：
1998-04-01
影响因子：
4.2
通讯作者：
Willett, WC
中科院分区：
文献类型：
--
作者：
Aldoori, WH;Giovannucci, EL;Willett, WC
为了前瞻性地检查基于分析技术和特定膳食纤维类型的食物成分值计算的膳食纤维与憩室病风险的关系，我们分析了来自43，881名美国男性健康专业人员的前瞻性队列数据，基线年龄为40-75岁;受试者没有诊断的憩室病，结肠或直肠息肉，溃疡性结肠炎和癌症。纤维的不溶性成分与憩室病的相对危险度（RR）呈负相关（RR = 0.63，95%置信区间（CI），0.44-0.91，趋势P = 0.02），纤维素的这种相关性尤其强（RR = 0.52，95% CI，0.36-0.75，趋势P = 0.002）。用AOAC标准方法计算的憩室病和总膳食纤维摄入量之间的关系与用索斯盖特或Englyst方法计算的结果没有明显差异[AOAC方法，RR = 0.60，95%CI，0.41-0.87;索斯盖特方法，RR = 0.61，95%CI，0.42-0.88;对于Englyst方法，RR = 0.60，95%CI，0.42-0.87，对于最高五分位数]。我们的研究结果为高膳食纤维饮食降低憩室病风险的假设提供了证据，并且该结果对使用不同的分析技术来定义膳食纤维并不敏感。我们的研究结果表明，纤维的不溶性成分与憩室疾病的风险降低显著相关，这种负相关性对纤维素特别强。
To examine prospectively dietary fiber calculated from food composition values based on analytic techniques and specific dietary fiber types in relation to risk of diverticular disease, we analyzed data from a prospective cohort of 43,881 U.S. male health professionals 40-75 y of age at base line; subjects were free of diagnosed diverticular disease, colon or rectal polyps, ulcerative colitis and cancer. The insoluble component of fiber was inversely associated with risk of diverticular disease relative risk (RR) = 0.63, 95% confidence interval (CI), 0.44-0.91, P for trend = 0.02, and this association was particularly strong for cellulose (RR = 0.52, 95% CI, 0.36-0.75, P for trend = 0.002). The association between diverticular disease and total dietary fiber intake calculated from the AOACstandards method was not appreciably different from results using the Southgate or Englyst method [for AOAC method, RR = 0.60, 95% CI, 0.41-0.87; for Southgate method, RR = 0.61, 95% CI, 0.42-0.88; for Englyst method, RR = 0.60, 95% CI, 0.42-0.87, for the highest quintiles]. Our findings provide evidence for the hypothesis that a diet high in dietary fiber decreases the risk of diverticular disease, and this result was not sensitive to the use of different analytic techniques to define dietary fiber. Our findings suggest that the insoluble component of fiber was significantly associated with a decreased risk of diverticular disease, and this inverse association was particularly strong for cellulose.