Measures of maternal tobacco exposure and infant birth weight at term
Measures of maternal tobacco exposure and infant birth weight at term
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DOI：
10.1093/aje/153.10.954
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发表时间：
2001-05-15
影响因子：
5
通讯作者：
Hannon, WH
中科院分区：
文献类型：
--
作者：
England, LJ;Kendrick, JS;Hannon, WH
这项研究是为了确定怀孕期间自我报告的每天吸烟数量与尿可替宁浓度的关系，并检查这两种烟草暴露指标与新生儿体重之间的关系。数据来自1987至1991年间实施的孕期戒烟项目。收集了3395名自我报告的吸烟者的吸烟信息和尿可替宁浓度，这些吸烟者在美国三个州(科罗拉多州、马里兰州和密苏里州)的公共诊所接受产前护理，并分娩了足月婴儿。一般线性模型被用来量化由每天吸烟的香烟数量解释的尿可替宁变异性，并产生不同烟草暴露水平的妇女的平均调整出生体重。自我报告的每天吸烟数量只解释了尿可替宁浓度变异性的13.9%。出生体重随着烟草暴露的增加而下降；然而，这种关系并不是线性的。出生体重的下降幅度最大的是低水平的暴露。此外，尿可替宁浓度不能解释比吸烟数量更多的出生体重变异性。研究减少吸烟对生育结果的影响的研究人员应该考虑这些发现。
This study was undertaken to determine the relation between self-reported number of cigarettes smoked per day and urine cotinine concentration during pregnancy and to examine the relations between these two measures of tobacco exposure and birth weight. Data were obtained from the Smoking Cessation in Pregnancy project, conducted between 1987 and 1991. Cigarette smoking information and urine cotinine concentration were collected for 3,395 self-reported smokers who were receiving prenatal care at public clinics in three US states (Colorado, Maryland, and Missouri) and who delivered term infants. General linear models were used to quantify urine cotinine variability explained by the number of cigarettes smoked per day and to generate mean adjusted birth weights for women with different levels of tobacco exposure. Self-reported number of cigarettes smoked per day explained only 13.9% of the variability in urine cotinine concentration. Birth weight declined as tobacco exposure increased; however, the relation was not linear. The sharpest declines in birth weight occurred at low levels of exposure. Furthermore, urine cotinine concentration did not explain more variability in birth weight than did number of cigarettes smoked. These findings should be considered by researchers studying the effects of smoking reduction on birth outcomes.