Anticancer Potential of Citrus Juices and Their Extracts: A Systematic Review of Both Preclinical and Clinical Studies.
Anticancer Potential of Citrus Juices and Their Extracts: A Systematic Review of Both Preclinical and Clinical Studies.
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DOI：
10.3389/fphar.2017.00420
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发表时间：
2017
影响因子：
5.6
通讯作者：
Navarra M
中科院分区：
文献类型：
--
作者：
Cirmi S;Maugeri A;Ferlazzo N;Gangemi S;Calapai G;Schumacher U;Navarra M
背景资料：在过去的几十年里，积累了大量的证据表明柑橘类水果及其果汁可能在预防包括癌症在内的许多疾病中发挥作用。目的：综述柑橘类果汁及其提取物作为抗肿瘤药物的研究进展。数据来源：由两名评审员独立对使用MEDLINE（1946年至今）、EMBASE（1974年至今）和Web of Sciences（1970年至今）撰写的英文文章进行系统性综述。检索词包括柑橘、Citrus aurantifolia、Citrus sinensis、Citrus paradisi、Citrus fruits、Citrus fruits extract、cancer、neoplasm、neoplasm、tumor、metastasis、carcinogenesis、proliferation。最后一次检索于2017年3月16日进行。研究选择：根据系统性综述和荟萃分析的首选报告项目（PRISMA）声明进行研究选择和系统性综述。在开始审查之前，作者定义了入选标准的清单，因此包括符合以下条件的文章：（i）在同行评审的科学期刊上发表;（ii）单独使用柑橘汁;（iii）柑橘汁提取物;（iii）对于临床前研究，柑橘汁及其提取物的暴露时间超过24小时。排除综述、荟萃分析、会议摘要和书籍章节。数据提取：三名评审员独立进行文章提取。资料综合：22篇符合纳入标准，符合纳入最终综述的条件。根据研究类型，将入选研究进一步分为临床前研究（n = 20）和观察性研究（n = 2）。结论：在这篇综述中讨论的研究有力地证实了柑橘汁及其衍生物作为潜在抗癌资源的作用。
Background: During the last decades, a huge body of evidence has been accumulated suggesting that Citrus fruits and their juices might have a role in preventing many diseases including cancer. Objective: To summarize the numerous evidences on the potential of Citrus juices and their extracts as anticancer agents. Data sources: A systematic review of articles written in English using MEDLINE (1946-present), EMBASE (1974-present) and Web of Sciences (1970-present) was performed independently by two reviewers. Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus fruits, Citrus fruits extract, cancer, neoplasm, neoplasia, tumor, metastasis, carcinogenesis, proliferation. The last search was performed on March 16th, 2017. Study selection: Study selection and systematic review were carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Prior to the beginning of the review, Authors defined a checklist for inclusion criteria, thus including articles which meet the following: (i) published on peer-reviewed scientific journals; (ii) Citrus juice used alone; (iii) extracts derived from Citrus juice; (iii) for preclinical studies, an exposure time to Citrus juices and their extracts more than 24 h. Reviews, meta-analyses, conference abstracts and book chapters were excluded. Data extraction: Three reviewers independently performed the extraction of articles. Data synthesis: 22 papers met our inclusion criteria and were eligible for inclusion in the final review. According to the kind of study, the selected ones were further divided in preclinical (n = 20) and observational (n = 2) studies. Conclusion: The studies discussed in this review strongly corroborate the role of Citrus juices and their derivatives as potential resource against cancer.