Synthesis and biological activity of Citridone A and its derivatives
Synthesis and biological activity of Citridone A and its derivatives
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DOI：
10.1038/ja.2014.14
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发表时间：
2014-03
期刊：
影响因子：
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通讯作者：
T. Fukuda;Kenta Shimoyama;T. Nagamitsu;H. Tomoda
中科院分区：
文献类型：
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作者：
T. Fukuda;Kenta Shimoyama;T. Nagamitsu;H. Tomoda
Citridone A（1）最初是从真菌培养液中分离出来的抗真菌咪康唑活性增强剂，具有苯基-R-呋喃并吡啶酮结构。由于其独特的环状结构，我们化学合成了11个衍生物，并对其生物活性进行了评价。衍生物17、20和21增强了咪康唑对白色念珠菌的活性。此外，发现1、14、20和21抑制耐甲氧西林金黄色葡萄球菌中的黄色素产生。
Citridone A (1), originally isolated as a potentiator of antifungal miconazole activity from a fungal culture broth, has a phenyl-R-furopyridone structure. Because of its unique ring structure, 11 derivatives were chemically synthesized and their biological activity was evaluated. Derivatives 17, 20 and 21 potentiated miconazole activity against Candida albicans. Furthermore, 1, 14, 20 and 21 were found to inhibit yellow pigment production in methicillin-resistant Staphylococcus aureus.