Adverse drug reactions to self-medication: a study in a pharmacovigilance database
Adverse drug reactions to self-medication: a study in a pharmacovigilance database
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DOI：
10.1111/fcp.12140
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发表时间：
2015-10-01
影响因子：
2.9
通讯作者：
Montastruc, Jean-Louis
中科院分区：
文献类型：
--
作者：
Berreni, Aurelia;Montastruc, Francois;Montastruc, Jean-Louis
尽管自我药疗已得到广泛发展，但有关其药物不良反应（ADR）的详细数据却很少。本研究调查了 2008 年至 2014 年 Midi-Pyrenees PharmacoVigilance 记录的自我药疗 ADR 的主要特征。自我药疗包括第一种非处方药和第二种先前处方药物，后来在未经医生建议的情况下使用（重复使用先前处方药物）。在记录的 12 365 份通报中，有 160 份（1.3%）与 SM 相关，涉及 186 种药物。大约四分之三的 ADR 是“严重的”。平均年龄为 48.8 岁，其中 56.3% 为女性。最常见的不良反应是胃肠道和神经精神药物，主要药物类别涉及非甾体抗炎药、镇痛药和苯二氮卓类药物。植物疗法-顺势疗法占药物的9.1%。
Although self-medication is widely developed, there are few detailed data about its adverse drug reactions (ADRs). This study investigated the main characteristics of ADRs with self-medication recorded in the Midi-Pyrenees PharmacoVigilance between 2008 and 2014. Self-medication included first OTC drugs and second formerly prescribed drugs later used without medical advice (reuse of previously prescribed drugs). Among the 12 365 notifications recorded, 160 (1.3%) were related to SM with 186 drugs. Around three-forth of the ADRs were 'serious'. Mean age was 48.8 years with 56.3% females. The most frequent ADRs were gastrointestinal and neuropsychiatric and main drug classes involved NSAIDs, analgesics, and benzodiazepines. Phytotherapy-homeopathy accounted for 9.1% of drugs.