Domino reactions for library synthesis of small molecules in combinatorial chemistry.
Domino reactions for library synthesis of small molecules in combinatorial chemistry.
复制标题
组合化学中小分子文库合成的多米诺反应。
DOI：
10.1016/s1367-5931(98)80010-0
复制
发表时间：
1998
影响因子：
7.8
通讯作者：
M. Lieb
中科院分区：
文献类型：
--
作者：
L. Tietze;M. Lieb
多米诺反应是一种高效的过程，可以从简单的底物开始以简单的方式合成复杂的分子。如果采用多组分多米诺反应，这些转换对于通过组合化学设计小分子库是非常有用的。该反应可以在溶液中进行，也可以在固体支持物上进行，并且可以获得高度多样化的分子;此外，它们可以用于自动化合成。
Domino reactions are highly efficient processes that allow the synthesis of complex molecules starting from simple substrates, in a straightforward fashion. The transformations are extremely useful for the design of small-molecule libraries by combinatorial chemistry if multicomponent domino reactions are employed. The reactions can be performed in solution, as well as on solid support, and give access to highly diverse molecules; in addition, their use in automated synthesis is possible.