T cells in psoriatic arthritis.
T cells in psoriatic arthritis.
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DOI：
10.1007/s11926-007-0071-5
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发表时间：
2007-12-01
影响因子：
5
通讯作者：
Choy, Ernest
中科院分区：
文献类型：
--
作者：
Choy, Ernest
银屑病关节炎的特征是皮肤和滑膜关节的慢性炎症。发炎的关节和皮肤中有大量的T细胞。疾病易感性与主要组织相容性复合体有关，主要组织相容性复合体将抗原呈递给T细胞。滑膜关节中的T细胞具有激活的表型，并显示T细胞受体的选择性使用，提示有寡克隆性扩张。综上所述，这些事实表明，银屑病关节炎是由抗原或自身抗原驱动的T细胞激活驱动的。抗T细胞药物的治疗益处进一步支持了T细胞在银屑病关节炎的持续性滑膜炎症和关节损害中的重要致病作用。
Psoriatic arthritis is characterized by chronic inflammation of the skin and synovial joint. T cells are abundant in the inflamed joint and skin. Disease susceptibility is associated with major histocompatibility complex, which presents antigens to T cells. T cells in the synovial joints have an activated phenotype and demonstrate selective T-cell receptor usage suggestive of oligoclonal expansions. Taken together, these facts suggest that psoriatic arthritis is driven by antigen or autoantigen-driven T-cell activation. The therapeutic benefit of anti-T-cell agents further supports an important pathogenic role for T cells in persistent synovial inflammation and joint damage in psoriatic arthritis.