Experimental verification of therapeutic doses for the superficially-placed tumor radiotherapy with heavy ions at HIRFL
Experimental verification of therapeutic doses for the superficially-placed tumor radiotherapy with heavy ions at HIRFL
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DOI：
10.1088/1674-1137/33/2/014
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发表时间：
2009-02
影响因子：
3.6
通讯作者：
Li Xinguo;L. Qiang;Wu Qing-feng;Tao Jia-Jun;J. Xiaodong
中科院分区：
文献类型：
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作者：
Li Xinguo;L. Qiang;Wu Qing-feng;Tao Jia-Jun;J. Xiaodong
截至目前，自2006年11月起，中国科学院近代物理研究所兰州重离子研究装置（HIRFL）已开展六次浅表肿瘤重离子放射治疗临床试验，已入选60余例患者接受80～100MeV/u碳离子治疗，开发了碳离子束被动照射系统和剂量优化方法。在HIRFL治疗终端模拟患者治疗的情况下，对纵向治疗剂量分布进行了实验验证。实测深度剂量分布与预期基本一致。这些结果表明，该照射系统和剂量优化方法在HIRFL正在进行的浅层肿瘤碳离子放射治疗中是有效的。
Up to now, clinical trials of heavy-ion radiotherapy for superficially placed tumors have been carried out for six times and over 60 selected patients have been treated with 80—100 MeV/u carbon ions supplied by the Heavy Ion Research Facility in Lanzhou (HIRFL) at the Institute of Modern Physics, Chinese Academy of Sciences since November, 2006. A passive irradiation system and a dose optimization method for radiotherapy with carbon-ion beams have been developed. Experimental verification of longitudinally therapeutic dose distributions was conducted under the condition of simulating patient treatment in the therapy terminal at HIRFL. The measured depth-dose distributions basically coincide with the expected ones. These results indicate that the irradiation system and the dose optimization method are effective in the ongoing carbon-ion radiotherapy for shallow-seated tumors at HIRFL.